NCT00975052已完成1 期
A Randomized, Placebo-Controlled, Double-Blind, Double-Dummy, Four-Period Crossover Study to Assess the Effects of Concomitant Administration of MK0431 and Metformin Alone and in Combination on Post-Meal Incretin Hormone Concentrations in Healthy Adult Subjects
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 16
- 主要终点
- Weighted average active GLP-1 (glucagonlike peptide-1) concentrations
研究概览
简要总结
This study will determine the effect of concomitant administration of sitagliptin and metformin on post-meal incretin hormone concentrations in healthy adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subject is in good health
- •Subject has been a nonsmoker for at least 6 months
- •Subject is willing to avoid strenuous activity from the screening visit until the end of the study
- •Subject agrees not to consume grapefruit products during the study and to avoid all fruit juices 24 hours before and after study drug administration
排除标准
- •Any history of stroke or neurological disorder
- •Subject has a history of cardiovascular, blood, endocrine or liver diseases
- •Subject has a history of cancer
研究组 & 干预措施
A
Active Comparator
Sitagliptin alone
干预措施: sitagliptin phosphate (Drug)
结局指标
主要结局
Weighted average active GLP-1 (glucagonlike peptide-1) concentrations
时间窗: 4 hours after the postdose meal
次要结局
未报告次要终点
研究者
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