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临床试验/NCT04559659
NCT04559659Unknown不适用

Study of the Relationship Between Respiratory Muscle Strenght, Peripheral Muscle Blood Flow and Gait Speed in the Elderly

Hospital Israelita Albert Einstein1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2019年8月20日最近更新:
适应症

试验速览

阶段
不适用
入组人数
50
试验地点
1
主要终点
Peripheral muscle blood flow, gait speed and handgrip strength

研究概览

简要总结

The pourpose of this study is to verify if have relationship between respiratory muscle strenght, peripheral muscle blood flow and gait speed in the elderly.

详细描述

The hypothesis of this study is that elderly with inspiratory muscle weakness will present lower peripheral blood flow and consequently lower walking speed. The main aim of the study is to verify if the peripheral muscular blood flow in the elderly is different between patients with and without decrease in inspiratory muscle strength. As secondary objectives, it will be evaluated the correlation between inspiratory muscle strength and gait speed and quality of life, as well as gait speed and peripheral muscle blood flow. Fifty elderly patients of both sexes, over 65 years, from Vila Mariana Einstein Outpatient Clinic and Cora Residencial Senior, will be included to evaluate Maximum Inspiratory Pressure (Pimáx), Maximum Expiratory Pressure (Pemáx), Spirometry (FVC, PF, FEV1), 4.6m Walk Test, Quality of life for the elderly (WHOQOL old), Mini Mental Test, Body Mass Index (BMI) and peripheral muscle blood flow by venous occlusion plethysmography.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Cross Sectional

入排标准

年龄范围
65 Years 至 100 Years(Older Adult)
性别
All
接受健康志愿者

入选标准

  • Elderly of both sexes, over 65 years old

排除标准

  • Mini Mental Test <24
  • Morse ≥ 51
  • Clinical instability, according to medical assessment • Structural heart disease, with ejection fraction <50% and chronic lung diseases with FEV1 <50% predicted,
  • Neurological, orthopedic, or neuromuscular diseases that prevent the performance of evaluations
  • Smokers or ex-smokers <5 years

结局指标

主要结局

Peripheral muscle blood flow, gait speed and handgrip strength

时间窗: Day 1

Check if there is a correlation between peripheral muscle blood flow, gait speed and handgrip strength and if this association is mediated by inspiratory muscle strength.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Luciana Diniz Nagem Janot Matos

PhD

Hospital Israelita Albert Einstein

研究点 (1)

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