Uppsala Intensive Care Study of Mechanisms for Organ Dysfunction in Covid-19
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 380
- 试验地点
- 1
- 主要终点
- Acute Kidney Injury
研究概览
简要总结
The study aims to investigate organ dysfunction and biomarkers in patients with suspected or verified COVID-19 during intensive care at Uppsala University Hospital.
详细描述
Consenting patients with suspected or verified SARS-COV-2 infection, COVID-19, will undergo daily blood, urine and sputum sampling during their stay in intensive care. Data on organ dysfunction will be collected through the electronic patient journal and electronic patient data management system. The collected samples will be analysed for a panel of potential biomarkers that will be correlated to organ dysfunction and clinical outcome.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Admitted to intensive care
- •suspected or verified COVID-19
排除标准
- •Pregnancy or breastfeeding
- •Under-age
研究组 & 干预措施
COVID-19
Patients with suspected or verified COVID-19 admitted to intensive care at Uppsala University Hospital
结局指标
主要结局
Acute Kidney Injury
时间窗: During Intensive Care, an estimated average of 10 days.
KDIGO AKI score
次要结局
- ARDS(During intensive care, an estimated average of 10 days.)
- 30 day mortality(30 days)
- SOFA-score(During Intensive Care, an estimated average of 10 days.)
- Chronic Kidney Disease(60 days and 1 year after ICU admission)
- ICUAW(During intensive care or after intensive care)
- 1 year mortality(1 year)
- Thromboembolic events(During intensive care)
研究者
Robert Frithiof
Associate Professor
Uppsala University