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Short term effects of adaptive servoventilation and continuous positive airway pressure in patients with central sleep apnea and Cheyne-Stokes Respiration

Klinik für Schlafmedizin und neuromuskuläre Erkrankungen Universitätsklinikum Münster0 个研究点目标入组 40 人开始时间: 2018年3月16日最近更新: 2024年8月19日

适应症

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•a. Age > 18 years (no age limit) (Group 1, 2 and 3)
•b. able to consent (Group 1, 2 and 3)
•c. predominant central sleep apnoea as defined as AHI>15/h and >50% central events and a central AHI >10/h derived from full overnight attended polysomnography (Group 1, 2 and 3)
•d. Diagnosis of Nizza class I pumonary arterial Hypertension -PAH- and heart failure with reduced ejection fraction -HFrEF- according to the most recent Guidelines of the European Society of Cardiology (ESC); >12 weeks since the diagnosis of HFrEF / PAH has been made; no hospitalisation for HF in the last 4 weeks; optimal medical therapy in accordance with the most recent Guidelines of the European Society of Cardiology (ESC) with no change in medication in the last 4 weeks and combination therapy for both PAH and HFrEF -where there was no treatment with combination therapy in PAH patients or with beta blockers or ACE Inhibitors/ARBs in HFrEF, then the reason must be documented-) (Group 1 and 2)
•e. Controls (matched for age and gender) with idopathic central sleep apnoea with normal findings on echocardiogram, electrocardiogram and normal levels of natriuretic peptide hormone (Group 3)

•- other severe internistic pre-existing conditions, especially insulin-dependent diabetes or severe renal impairment -intake of opiods
•- severe psychiatric pre-existing conditions

发起方

Klinik für Schlafmedizin und neuromuskuläre Erkrankungen Universitätsklinikum Münster