Studying Cognitive Outcome of Renal Transplantation with a Kidney of a Live Donor - SCORE

Academisch Medisch Centrum0 个研究点目标入组 62 人开始时间: 待定最近更新: 2024年4月29日

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•* Patients undergoing a scheduled renal transplantation with a live kidney donor before having started dialysis or within one year after starting dialysis and their donors.
•* Sufficient visual and hearing acuity
•* Dutch or English language fluency
•* Willingness to give informed consent
•* ABO compatible

•* Pre-existing documented cognitive impairment
•* A history of psychiatric illness
•* Use of psychoactive substances
•* A history of cerebrovascular disease (either transitory ischaemic attack or cerebrovascular accident)
•* Brain injury
•* Epilepsy
•* Acute or chronic infections
•* Malignancy
•* Unstable coronary vascular disease
•* Uncontrolled hypertension
•* Liver disease or other metabolic disease leading to encephalopathy
•* Diabetes mellitus
•* Uncorrected anemia (Hb <7,0 mmol/L)
•* MR contraindications, including implanted active devices or objects (e.g. cardiac pacemaker, implantable defibrillator, medication pump, intracranial aneurysm clips, cochlear implant and other implants), metal splinters near sensitive organs (e.g. eye, brain or lungs) or claustrophobia.
•* Any condition that can be expected to interfere with complete follow-up
•* Patients participating in group 1 of the ALLEGRO trial
•* HLA-identical family transplantations

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