Exendin-9,39 and Satiety After Bariatric Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 29
- 试验地点
- 1
- 主要终点
- Caloric Intake
研究概览
简要总结
The overall aim of the application is to determine the contribution of the elevated incretin hormone concentrations seen after certain types of bariatric surgery to the regulation of food intake and satiety.
详细描述
Both Sleeve Gastrectomy (SG) and Roux-en-Y Gastric Bypass (RYGB) increase GLP-1 concentrations, although this is of lesser magnitude in SG compared to RYGB. Data suggests that endogenous GLP-1 is at least partially responsible for reducing free-choice caloric intake after RYGB, providing a mechanism underlying differences between procedures. Inhibition of GLP-1 action with Exendin-9,39 after RYGB accelerates gastric emptying. These observations suggest that factors other than anatomy regulate the upper gastrointestinal response to food ingestion. It is therefore reasonable to consider that the postprandial rise in GLP-1 might affect feeding behavior after RYGB, and to a lesser extent SG, where the increase in GLP-1 is less marked.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Undergone either sleeve gastrectomy or Roux-en-Y Gastric Bypass surgery within prior 2 years
- •Healthy, with no active systemic illness
排除标准
- •Pregnancy
- •Functional or organic bowel symptoms
- •Systemic illness
- •Bariatric surgery > 2 years
研究组 & 干预措施
Saline
0.9% NaCL (saline) intravenously for 6 hours.
干预措施: Saline (Drug)
Exendin-9,39
Exendin-9,39 intravenously for 6 hours.
干预措施: Exendin-9,39 (Drug)
结局指标
主要结局
Caloric Intake
时间窗: 5 hours
caloric intake from a free choice buffet within 5 hours after ingestion of a standard meal
次要结局
- Gastrointestinal Transit Measured Using Scintigraphy(4 hours)
研究者
Adrian Vella
MD, FRCP (Edin), Consultant Division or Endocrinolgy, Diabetes and Nutrition
Mayo Clinic