Mega-dose Vitamin C for patients with septic shock: a pilot randomised controlled trial

Professor Rinaldo Bellomo0 个研究点目标入组 30 人开始时间: 2020年6月5日最近更新: 2022年8月9日

适应症

试验速览

暂无简介。

•Suspected or confirmed septic shock defined as an acute increase of:
•- equal to or greater than 2 sequential organ failure assessment (SOFA) points
•- need for continuous intravenous vassopressor therapy to maintain a mean arterial blood pressure of greater than 65 mmHg for greater than 2 hours and a serum lactate of greater than 2 mmol/L (despite adequate fluid resuscitation) within the previous 24 hours.

•Aged less than 18 years
•Suspected or confirmed pregnancy
•Do not resuscitate or do not intubate order
•Death is deemed to be imminent or inevitable during this index hospital admission
•Patients with know human immunodeficiency virus (HIV) infection
•Patients with known glucose-6 phosphate dehydrogenanse (G-6PD) deficiency
•Patients transferred from another intensive care unit or hospital with a diagnosis of septic shock for greater than 24 hours
•Patient with known chronic iron overload due to iron storage and other diseases
•Patient previously enrolled in this study
•Patients with chronic haemodialysis or peritoneal dialysis.
•Patients require renal replacement therapy within next 24 hours.
•Patients baseline blood sodium level is equal to or greater than 155 mEq/L
•Patients creatinine at enrolment is equal to or greater than 150 mmol/L
•Patients with known or suspected:
•- history of oxalate nephropathy or hyperoxaluria
•- short blow syndrome or severe fat malabsorption
•- acute beri-beri disease
•- acute Wernicke's encephalopathy

发起方

Professor Rinaldo Bellomo