Immunological and Cardiovascular Phenotyping of Oocyte-donation Pregnancies
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Preeclampsia in oocyte-donation pregnancies is caused by an altered composition of immune cells in placenta and blood.
研究概览
简要总结
The investigators conduct a study to evaluate the underlying causes of preeclampsia in oocyte-donation pregnancies.
详细描述
A detailed medical history, questionnaires as well as blood, urine and placental samples will be used to analyse several factors leading to the high risk of preeclampsia in oocyte-donation pregnancies.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •pregnancy
排除标准
- •severe auto immune disorders
结局指标
主要结局
Preeclampsia in oocyte-donation pregnancies is caused by an altered composition of immune cells in placenta and blood.
时间窗: 01.01.2020 - 01.12.2025
T-Cell populations are altered in preeclampsia. HLA-mismatch of mother and donor oocyte lead to a "host-versus-graft" reaction. T-, B- and Natural killer cells are altered in placental tissue of oocyte-donation pregnancies.
次要结局
- Preeclampsia in oocyte-donation pregnancies is caused by an activation of pro-inflammatory factors and endothelial dysfunction.(01.01.2020 - 01.12.2025)
研究者
Florian Herse
Doctor of Science
Charite University, Berlin, Germany