Comprehensive Precision Oncology Program at The Chinese University of Hong Kong
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 170
- 试验地点
- 2
- 主要终点
- Construction of a personalized drug screening platform for individuals using novel cancer models established from patient-derived cancer cells and tissues.
研究概览
简要总结
The main aim of this project is to establish an innovative model of a comprehensive precision oncology platform to help individualizing drug therapy for patients with advanced cancers at The Chinese University of Hong Kong. The other objectives include to optimize the genomic matching and access of patients with unique cancer subtypes to the relevant clinical trials of novel therapies, and to construct a personalized drug screening platform for individuals using novel cancer models established from patient-derived cancer cells and tissues. Other objectives include to investigate the utility and feasibility of genomic sequencing using circulating tumor DNA(ctDNA), and to establish a biobank of tumor tissues derived from patients with unique cancer subtypes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Must be aged between 18 to 75 years
- •Must have ECOG performance status of 0 to 1
- •Must have histologically/cytologically confirmed cancers of certain subtype
- •Medically fit patients who would need systemic therapy as part of their oncological treatment in any one or more of the following oncological setting(s): palliative, neoadjuvant, adjuvant, concurrent with radiotherapy. This includes patients who have limited systemic therapeutic options for their cancers and are candidates for clinical trials.
- •Able to give written informed consent
- •Willing to have blood samples taken.
- •Availability of an archived paraffin-embedded tumor block
排除标准
- •Patients who refuse or are medically unfit for systemic therapy for their cancer
- •Patients with more than one invasive cancers diagnosed over the last FIVE years.
- •Patients without measurable tumor lesions on radiological imaging
- •Patients who are unable to give written informed consent.
结局指标
主要结局
Construction of a personalized drug screening platform for individuals using novel cancer models established from patient-derived cancer cells and tissues.
时间窗: 4 years
Establishment of an innovative model of a comprehensive precision oncology platform
时间窗: 4 years
次要结局
- Describe the prevalence of actionable genomic aberrations in patients with advanced cancers in Hong Kong(4 years)
研究者
Brigette Ma
Professor, Department of Clinical Oncology
Chinese University of Hong Kong