Behavioural Addiction and Genetics in Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 332
- 试验地点
- 1
- 主要终点
- Allele frequency of 50 genetic markers (polymorphisms) will be compared between cases and controls.
研究概览
简要总结
The " Behavioural Addiction and Genetics in Parkinson's Disease " study (BADGE-PD) is a national (France), multicenter, genetic association, case-control study to identify genetic factors associated with behavioural addiction (or Impulse Control Disorders, ICD) related to dopamine agonists treatment in Parkinson's disease (PD). Polymorphisms of candidate genes supposed to be involved in this adverse effect will be compared in 200 PD patients with ICD (n=200) and 200 matched PD patients without ICD (n=200).
详细描述
Objective: To identify susceptibility genes to impulse control disorders in Parkinson's Disease.
Study design: Genetic association study.
Primary objective:
To identify the susceptibility genes in behavior addiction in Parkinson's Disease
Secondary endpoints:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Allele frequency of 50 genetic markers (polymorphisms) will be compared between cases and controls.
时间窗: baseline
次要结局
- Total UPDRS (Unified Parkinson's Disease Rating Scale) score(baseline)
- number of patients with a diagnostic of ICD according to the MINI(baseline)
- Total score of the MMSE (Mini Mental State Examination)(baseline)
- Sub scores at the temperament and Character Inventory (revised version, TCI-R)(baseline)
- Number of subject in each group with personal or familial history of addiction(baseline)