Comparative Study Of Ropivacaine Vs Levobupivacaine With Clonidine In Ultrasound Guided Adductor Canal Block For Postoperative Analgesia In Total Knee Arthroplasty
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Duration of postoperative analgesia, measured as the time from completion of the ultrasound-guided adductor canal block to the first request for rescue analgesia ( assessed using NRS pain score)
研究概览
简要总结
Adductor canal block is a regional anaesthesia technique increasingly used for postoperative analgesia in lower limb surgeries
Ropivacaine is a long acting amide local anaesthetic agent with less cardiotoxic effect compared to bupivacaine
Levobupivacaine show safer pharmacological profile with less cardiac and neurotoxic adverse effects
Clonidine is a frequently used adjuvant to local anaesthetic
This study aims to determine the efficacy of ropivacaine with clonidine vs levobupivacaine with clonidine for adductor canal block in total knee arthroplasty surgeries for postoperative analgesia
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 40.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients aged between 40 to 75 years of either gender giving written willingness consent.
- •Patient belonging to American Society of Anaesthesiology class 1 and 2 and scheduled for elective orthopedic Total knee arthroplasty surgeries under spinal Anaesthesia.
排除标准
- •Patients having history of coagulation abnormalities chronic kidney diseases chronic liver diseases Any history of allergy or contraindication to study drugs Any contraindication for neuroaxial anaesthesia.
结局指标
主要结局
Duration of postoperative analgesia, measured as the time from completion of the ultrasound-guided adductor canal block to the first request for rescue analgesia ( assessed using NRS pain score)
时间窗: Immediately after adductor canal block
次要结局
- Postoperative pain scores at rest & on movement using the Numerical Rating Scale (NRS) at 0,2,4,6,8,12, & 24 hours.(Total rescue analgesia consumption in the first 24 hours postoperatively)
研究者
Taranjot Singh
Guru Gobind Singh Medical College Hospital