ANalyzing Olfactory Dysfunction Mechanisms In COVID-19
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 150
- 试验地点
- 2
- 主要终点
- Prevalence of SARS-CoV-2 in the sampled tissue
研究概览
简要总结
We aim to understand the mechanism of olfactory dysfunction in COVID-19.
详细描述
In December 2019, a new coronavirus causing severe acute respiratory syndrome was described in Wuhan, China. This virus, later named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread worldwide and has been designated a pandemic by the World Health Organization.
By the beginning of March 2020, several Ear, Nose, Throat societies raised awareness of a frequent association between coronavirus disease 2019 (COVID-19) and smell disorders.
In the present study, the investigators wish to begin to understand the pathogenesis of olfactory dysfunction in COVID-19.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Deceased hospitalised patients, tested positive or negative for SARS-CoV-2 for patient or control group respectively
排除标准
- 未提供
结局指标
主要结局
Prevalence of SARS-CoV-2 in the sampled tissue
时间窗: Immediately after death
In the sampled tissues, the investigators will determine presence of SARS-CoV-2 by means of immunohistochemistry, RNA-scope and spatial transcriptomics
次要结局
未报告次要终点
研究者
Laura Van Gerven
Professor doctor
Universitaire Ziekenhuizen KU Leuven