The Impact of Single-shot Adductor Canal Block Versus Continuous Femoral Nerve Block on Rehabilitation After Total Knee Replacement (AdORe - ACB)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 220
- 试验地点
- 2
- 主要终点
- Ambulation distance
研究概览
简要总结
Total knee replacement (TKR) is considered the most effective and safe method of radical treatment of late stages of knee osteoarthritis. A well-known problem of TKR is a severe postoperative pain syndrome, which is observed in more than 50% of patients.
Femoral nerve block (FNB) is the "gold standard" for continuous postoperative analgesia after total knee replacement, as it is effective in reducing the frequency of use of opioid analgetics and reduce the duration of hospitalization. At the same time, the negative effect of this method is the motor blockade of the quadriceps femoris muscle which leads to functional impairment and is associated with an increased risk of falling.
Adductor canal block (ACB) provides adequate analgesia comparable to femoral nerve block. Moreover, ACB doesn't affect the motor function of the quadriceps femoris muscle.
The possibility of enhanced recovery after total knee replacement is the reason to compare single-shot adductor canal block and continuous femoral nerve block.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Planned primary total knee replacement
- •Planned neuraxial anesthesia
- •Written informed consent
排除标准
- •Urgent surgery
- •Planned revision total knee replacement
- •Known allergic reaction to anesthetics
- •Confirmed localized infection at the puncture sites
- •Confirmed localized tumor at the puncture sites
- •Peripheral neuropathy of the lower extremities
- •Parkinson's disease
- •Previously enrolled in this trial
研究组 & 干预措施
Single-shot adductor canal block
干预措施: Single-shot adductor canal block (Procedure)
Continuous femoral nerve block
干预措施: Continuous femoral nerve block (Procedure)
结局指标
主要结局
Ambulation distance
时间窗: postoperative day 1
Less meters means worse outcome
次要结局
- Timed up and go test(postoperative day 2)
- 10 meters walk test(postoperative day 2)
- length of hospitalization(30 day)
- 30 seconds chair stand test(postoperative day 2)
- Ambulation distance(postoperative day 2)
- 5 times sit to stand test(postoperative day 2)
- time to readiness to dicharge(30 day)
- Timed up and go test(postoperative day 1)
- 10 meters walk test(postoperative day 1)
- 30 seconds chair stand test(postoperative day 1)
- 5 times sit to stand test(postoperative day 1)
研究者
Valery Likhvantsev, MD
Head of the Research V. Negovsky Reanimatology Research Institute
Negovsky Reanimatology Research Institute