A comparison of two stem cells utilization methods; intravenous and intra alveolar injection by bronchoscopy on outcome of severe lung contusion in patients admitted to intensive care unit (ICU)

Kerman University of Medical Sciences0 个研究点目标入组 30 人开始时间: 待定最近更新: 2022年11月21日

试验速览

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•The pressure of arterial oxygen to inspiratory oxygen should be less than 180(PaO2/FIO2<180)
•Bilateral infiltration with pulmonary edema in anterior lung radiography
•Pulmonary contusion greater than 40% in chest CT scan
•The need to transfer to the intensive care unit due to respiratory failure
•Criteria 1-4 must all be present within a 24-hour period at the time of study entry

•More than 96 hours have passed since the patient's ARDS trauma
•Pregnant or lactating woman
•Presence of any active malignancy (other than nonmelanoma skin cancer) that requires treatment within 2 years
•Any irreversible disease such as malignancies and a condition with a 50% chance of death within the next six months
•Moderate to severe liver disorder based on Child-Puff criteria<12
•chronic obstructive pulmonary disease(COPD)
•The patient has undergone a lung transplant
•The patient's lack of consent, or if the patient is unable to answer, the patient's guardian's lack of consent
•A patient who is not expected to be alive in the next 24 hours according to the Apache criteria
•Class III or IV pulmonary hypertension
•Pulmonary embolism or deep vein thrombosis in the past three months
•Brain trauma
•Transfusion of large volume of blood (injection of more than 10 units of blood in the last 24 hours)
•The presence of heart failure, kidney and diabetes
•Patients in a state of shock and previous concurrent contusion

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