NCT02037308已完成不适用
The Effects of Beetroot Bread on Postprandial Blood Pressure According to Glu298Asp Polymorphism in the eNOS Gene
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Postprandial blood pressure
研究概览
简要总结
The Glu298Asp polymorphism has been linked to increased risk of cardiovascular events, proposed to be due to reduced nitric oxide production by eNOS reported in some but not all studies. We hypothesise that beetroot-enriched bread interacts with the Glu298Asp polymorphism of the eNOS gene to lower blood pressure and increase plasma nitrate/nitrite, particularly in carriers of the T allele, which have been associated with lower eNOS activity and increased risk of hypertension.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •A signed consent form
- •Age 18-64 years
- •Body mass index - 18.5-30 kg/m2
- •Non-smoking, healthy individuals
- •Normal blood pressure at screening (< 150/90)
排除标准
- •Subjects with anaemia
- •Sufferers of chronic illnesses
- •Individuals with food allergies
- •People with diabetes
- •People with coeliac disease
- •Vegetarians
结局指标
主要结局
Postprandial blood pressure
时间窗: 30 minute intervals for a period of 6 hours
次要结局
- Postprandial plasma NOx(30 minute intervals for a total period of 6 hours)
研究者
Julie Lovegrove
Professor
University of Reading
研究点 (2)
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