NCT02605330已完成不适用
Kinetics of Plasma Fibrinogen During Cardiac and Thoracic Aortic Surgery
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Plasma fibrinogen concentration
研究概览
简要总结
The study intends to measure fibrinogen plasma levels during the first 24 hrs in cardiac and thoracic surgical patients who undergo surgical procedures using extracorporeal circulation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective patients undergoing coronary artery bypass grafting, aortic valve replacement or thoracic aortic surgery
- •Signed written informed consent
排除标准
- •Participation in another study
- •Language barrier to understand study purposes (e.g. french as a native language)
- •Preoperative low level of plasma fibrinogen (< 1.75 g/l)
- •Preoperative anemia (Hb < 10g/dl)
- •Emergency treatment
- •Intake of anticoagulants other than aspirin within 14 days preceding surgery.
- •Known coagulation disorder.
- •Jehovah's witnesses
结局指标
主要结局
Plasma fibrinogen concentration
时间窗: through study completion, an average of 1 year
Conventional (Clauss) and thromboelastometric measurement (FIBTEM)
次要结局
- Periprocedural thromboembolic complications(through study completion, an average of 1 year)
- In-hospital mortality(through study completion, an average of 1 year)
- Platelet count(through study completion, an average of 1 year)
- Prothrombin time (Quick)(through study completion, an average of 1 year)
- Thoracic drain loss(through study completion, an average of 1 year)
- Intensive Care Unit (ICU) length of stay(through study completion, an average of 1 year)
- Thrombin concentration(through study completion, an average of 1 year)
- Activated partial thromboplastin time (aPTT)(through study completion, an average of 1 year)
- Thromboelastometric (ROTEM) parameters (e.g., INTEM, EXTEM, HEPTEM)(through study completion, an average of 1 year)
研究者
研究点 (1)
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