A Phase 2 Study to Evaluate LB1148 for the Treatment of Pulmonary Dysfunction Associated With COVID-19 Pneumonia
试验速览
- 阶段
- 2 期
- 状态
- 撤回
- 主要终点
- Effect of LB1148 on disease progression via measurement of the proportion of patients who are alive and free of respiratory failure.
研究概览
简要总结
This is a Phase 2, proof of concept, randomized, placebo-controlled, multicenter study to evaluate the ability of LB1148 to attenuate pulmonary dysfunction associated with COVID-19 pneumonia. The primary objective of this study is to determine if enteral administration of LB1148 will effect disease progression in hospitalized patients with moderate to severe COVID-19 via measurement of the proportion of subjects alive and free of respiratory failure at Day 28.
详细描述
The purpose of this study is to establish the safety and tolerability, along with preliminary evidence of efficacy, of LB1148 compared to placebo in hospitalized patients with moderate to severe coronavirus disease (COVID-19). All patients will be randomized into one of two treatment groups (LB1148 or Placebo) in a 1:1 ratio, and stratified by peripheral capillary oxygen saturation (SpO2) ≥ 93% on room air vs. < 93% on room air, and by PF ratio (PaO2, arterial oxygen partial pressure, to FiO2, fractional inspired oxygen) of ≥ 300 mmHg vs. PF ratio of < 300 mmHg at the time of Screening. (If PaO2 cannot be measured or acquired, SpO2 may be substituted to calculate the PF ratio.) LB1148 contains 7.5 g tranexamic acid (TXA), polyethylene glycol (PEG), glucose, and electrolytes. A total of 700 mL of LB1148 will be administered enterally, as a split dose (350 mL, every 12 hours). Study drug is given as a single bolus, to be delivered orally or via nasogastric (NG) or orogastric (OG) tube. For those patients assigned to placebo, a total of 700 mL of placebo will be administered enterally, as a split dose (350 mL, every 12 hours). The placebo contains PEG, glucose, and electrolytes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
盲法说明
Quadruple blinding including the sponsor and all sponsor agents, subjects, investigators, care providers, and family members.
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (18 years of age or older) with the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, confirmed via an established standard reverse transcriptase polymerase chain reaction (RT-PCR) assay.
- •Patient or patient's legally authorized representative is willing and able to provide informed consent prior to performing any study-related procedures.
- •Patient is hospitalized and requires some form of supplemental oxygen, e.g., non-invasive ventilation, high flow oxygen device, or oxygen by mask or nasal cannula.
- •Patient has radiographic evidence of pulmonary infiltrate(s) or lung inflammation.
排除标准
- •Participation in any other interventional clinical trial using an experimental treatment (drug or device) for COVID-
- •Expected survival or time to withdrawal of life-sustaining treatments is expected to be < 7 days.
- •Patients with do not intubate orders.
- •Patients who require invasive mechanical ventilation at the time of Screening.
- •Patients who require renal replacement therapy (RRT) at the time of Screening.
- •Patients with known aspiration problems.
- •Has contraindications or potential risk factors to taking TXA. These include patients with:
- •Known sensitivity to TXA;
- •Recent craniotomy (past 30 days);
- •Active cerebrovascular bleed;
- •Active thromboembolic disease (such as deep vein thrombosis, pulmonary embolism, cerebral thrombosis, ischemic stroke, or acute coronary syndrome);
- •Acute promyelocytic leukemia taking all-trans retinoic acid for remission induction
- •Continuing use of a combined hormonal contraceptive and or combined hormonal replacement therapy (including combined hormonal pill, patch, or vaginal ring).
- •Concomitant therapy with tissue plasminogen activators, Factor IX complex concentrates or anti-inhibitor coagulant concentrates.
- •Known medical history of congenital or acquired thrombophilia such as, but not limited to patients with:
- •Sickle cell disease
- •Nephrotic syndrome
- •Factor V Leiden
- •Prothrombin gene mutation
- •Protein C or S deficiency
- •Antithrombin III deficiency
- •Antiphospholipid syndrome
- •Patients with myeloproliferative disorders.
- •Any other condition that, in the opinion of the treating Investigator, would preclude the patient from being an appropriate candidate for the study.
- •Female patients who are pregnant or breastfeeding at the time of Screening.
研究组 & 干预措施
LB1148
LB1148 contains 7.5 g TXA, polyethylene glycol (PEG), glucose, and electrolytes. A total of 700 mL of LB1148 Active will be administered daily as a split dose (350 mL, every 12 hours) for up to 7 days. LB1148 Active is given as a single bolus, to be delivered orally or enterally via NG/OG tube, and should be fully consumed or delivered within 2 hours of the start of administration.
干预措施: LB1148 (Drug)
Placebo
Placebo contains polyethylene glycol (PEG), glucose, and electrolytes. A total of 700 mL of LB1148 Placebo will be administered daily as a split dose (350 mL, every 12 hours) for up to 7 days. LB1148 Placebo is given as a single bolus, to be delivered orally or enterally via NG/OG tube, and should be fully consumed or delivered within 2 hours of the start of administration.
干预措施: Placebo (Drug)
结局指标
主要结局
Effect of LB1148 on disease progression via measurement of the proportion of patients who are alive and free of respiratory failure.
时间窗: 28 Days
The proportion of subjects alive and free of respiratory failure at Day 28.
次要结局
- All-cause 28-day mortality(28 Days)
- Measurement of the number and proportion of patients requiring admission to the intensive care unit (ICU) during hospitalization(28 Days)
- Duration of ICU stay(28 Days)
- Invasive mechanical ventilation requirements(28 Days)
- Clinical status at fixed time points(Measured at 3, 5, 7, 8, 10, 14 and 28 Days)
- Duration of hospital stay(28 Days)
- Safety and tolerability of LB1148(28 Days)
- Duration of invasive mechanical ventilation(28 Days)