The Effect of Nitrate Supplementation: Source of Supplementation
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Plasma nitrite levels
研究概览
简要总结
The main aim of the current study will be to compare the effects of ingesting different nitrate-rich sources on plasma nitrite concentrations.
详细描述
Oral ingestion of nitrate (NO3-) has been shown to increase plasma nitrate and nitrite levels. Significant lowering of pulmonary oxygen uptake during exercise, as well as significantly lower blood pressure values at rest have been observed after supplementation with nitrate. However, no study has yet described a direct comparison between different nitrate-rich beverages with respect to the bioavailability of nitrate/nitrite and the possible hemodynamic effects. Based on the gaps in current literature, our main goal will therefore be to gain further insight into the effects of nitrate supplementation with different sources on plasma nitrite levels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18.5 < BMI < 30 kg/m2
- •Engagement in regular physical activity ( > 1 h a week)
排除标准
- •Use of medication
- •Currently supplementing diet with nitrate
- •Lactose intolerance
研究组 & 干预措施
Beetroot juice
Dietary supplement: 800 mg of nitrate in concentrated beetroot juice (Beet-IT)
干预措施: Rocket salad (Dietary Supplement)
Sodium nitrate
Dietary supplement: 800 mg of nitrate in sodium nitrate added with water to get a 140 mL solution (BASF, Ludwigshafen, Germany)
干预措施: Beetroot juice (Dietary Supplement)
Sodium nitrate
Dietary supplement: 800 mg of nitrate in sodium nitrate added with water to get a 140 mL solution (BASF, Ludwigshafen, Germany)
干预措施: Rocket salad (Dietary Supplement)
Spinach
Dietary supplement: 800 mg of nitrate in a spinach based beverage
干预措施: Rocket salad (Dietary Supplement)
Spinach
Dietary supplement: 800 mg of nitrate in a spinach based beverage
干预措施: Beetroot juice (Dietary Supplement)
Rocket salad
Dietary supplement: 800 mg of nitrate in a rocket salad based beverage
干预措施: Beetroot juice (Dietary Supplement)
Spinach
Dietary supplement: 800 mg of nitrate in a spinach based beverage
干预措施: Sodium nitrate (Dietary Supplement)
Rocket salad
Dietary supplement: 800 mg of nitrate in a rocket salad based beverage
干预措施: Spinach (Dietary Supplement)
Rocket salad
Dietary supplement: 800 mg of nitrate in a rocket salad based beverage
干预措施: Sodium nitrate (Dietary Supplement)
Sodium nitrate
Dietary supplement: 800 mg of nitrate in sodium nitrate added with water to get a 140 mL solution (BASF, Ludwigshafen, Germany)
干预措施: Spinach (Dietary Supplement)
Beetroot juice
Dietary supplement: 800 mg of nitrate in concentrated beetroot juice (Beet-IT)
干预措施: Spinach (Dietary Supplement)
Beetroot juice
Dietary supplement: 800 mg of nitrate in concentrated beetroot juice (Beet-IT)
干预措施: Sodium nitrate (Dietary Supplement)
结局指标
主要结局
Plasma nitrite levels
时间窗: Baseline until 5 hours after ingestion
Plasma nitrite levels following ingestion of dietary nitrate
次要结局
- Resting blood pressure(Baseline, 2.5 hours and 5 hours post-ingestion)
- Plasma levels of nitrate(Baseline until 5 hours post-ingestion)
- Tongue scraping to assess bacterial mouth flora.(5 h post-ingestion)