Mediators of Atherosclerosis in South Asians Living in America
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 2,314
- 试验地点
- 3
- 主要终点
- Coronary artery calcium prevalence in South Asians
研究概览
简要总结
South Asian (Indian, Pakistani, Bangladeshi, Nepali, and Sri Lankan) individuals have high rates of cardiovascular disease that is not explained by traditional cardiovascular risk factors. Though South Asians represent over one-quarter of the world's population, there are no longitudinal studies in this high-risk ethnic group. The investigators aim to establish a longitudinal study of South Asians at three United States centers to identify risk factors linked to subclinical atherosclerosis and incident cardiovascular disease. The purpose of this study is to understand the causes of heart disease and stroke in South Asians and compare these causes to those in other United States ethnic groups.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 84 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •South Asian ancestry defined by having at least 3 grandparents born in one of the following countries: India, Pakistan, Bangladesh, Nepal, or Sri Lanka
- •age between 40 and 84 years.
排除标准
- •Physician diagnosed heart attack, stroke or transient ischemic attack (TIA), heart failure, or angina (or use of nitroglycerin)
- •Current atrial fibrillation
- •Past history of cardiovascular procedures (coronary artery bypass graft (CABG) Surgery, angioplasty, valve replacement, pacemaker or defibrillator implantation, or any surgery on the heart or arteries)
- •Active treatment for cancer
- •Life expectancy less than 5 years due to serious medical illness
- •Impaired cognitive ability as judged by the reviewer
- •Plans to move out of the study region in next 5 years
- •Weight greater than 300 pounds
- •Living in a nursing home or on a waiting list
- •Unable to speak/read/write English, Hindi, Urdu, or Bangla
结局指标
主要结局
Coronary artery calcium prevalence in South Asians
时间窗: Baseline
次要结局
- Change from baseline Coronary artery calcium prevalence in South Asians at 4 years(Baseline to Year 4)
- Incidence of type 2 diabetes after approximately 4 years of follow-up(Baseline to Year 4)
- Carotid intima media thickness(Baseline)
- Diabetes Prevalence(Baseline)