Comparison of Analgesic Efficacy of Two Different Doses of Dexmedetomidine as Adjuncts to Lidocaine for Intravenous Regional Anesthesia: Randomized Clinical Trial.
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- The time to first analgesic request.
研究概览
简要总结
Intravenous Regional Anesthesia (IVRA) was first used by August Bier in 1908. This technique is easy to administer, reliable and cost-effective for short surgical procedures of the extremities performed on an ambulatory basis with success rate of approximately 95% - 100% .
Lidocaine becomes the local anesthetic of choice for Intravenous Regional Anesthesia (IVRA) because of the lack of cardiac toxicity and neurotoxicity. But, delayed onset of action, poor muscle relaxation and lack of postoperative analgesia are the major limitations of this technique. Accordingly, many additives have been tried to overcome this problem. Muscle relaxants, ketamine,ketorolac, clonidine and opioids are examples of these adjuvants, and their effects have been studied in detail.
An ideal anesthetic agent for IVRA should have rapid analgesic effect to reduce tourniquet pain and its effects should last longer enough after deflating tourniquet. To achieve this, other drugs including narcotics, nonsteroidal anti-inflammatory drugs, ketorolac, clonidine, nitroglycerin (TNG), dexmedetomidine, magnesium, and neostigmine were used in combination with lidocaine in different studies. This study aims 1- To compare the anesthetic and analgesic efficacy of Dexmedetomidine and lidocaine versus lidocaine only during IVRA (Bier's block) and 2-To compare anesthetic and analgesic efficacy of different doses of dexmedetomidine when used as adjuvants to lidocaine during IVRA (Bier's block).
详细描述
Preoperative evaluation of the patients will be done including medical history, physical examination, and laboratory investigations. Patients should be in fasting state for at least 8 h before surgery, and the visual analog scale (VAS) (from 0 to 10: 0 = no pain up to 10 = severe pain) will be explained to the patients to express their pain.
On arriving at the operating room, routine intraoperative monitors will be applied, such as a noninvasive blood pressure monitor, a five-lead ECG, and a pulse oximeter. Two (20 G) venous cannulae will be inserted, one in the dorsum of the operative hand and one in the other hand, for fluid infusion during surgery and for any intravenous medications.
Patients will be premedicated with IV 0.05 mg/Kg of midazolam. After the patient is taken to the operating room, mean arterial blood pressure (MAP), peripheral oxygen saturation (SPO2) and heart rate (HR) will be monitored. The operative arm will be elevated for 2 minutes then exsanguinated with an esmarch bandage. A pneumatic double tourniquet will be placed a round upper arm, and the proximal cuff will be inflated to 250 mmHg. Circulatory isolation of the arm will be verified by inspection, absence of radial pulse, and loss of pulse oximetry tracing in the ipsilateral index finger. After the bandage is removed, 40 ml of the respective solutions will be injected over 20 seconds by an anesthesiologist.
The Sensory block will be assessed by pinprick performed with a 22-gauge needle every 30 seconds until the dermatomal sensory block of medial and antebrachial cutaneous, ulnar, median and radial nerves achieved. Motor function will be assessed by asking the patients to flex and extend his/her wrist and fingers and complete motor block will be noted when no voluntary movement is possible. Sensory block onset time will be noted as the time elapsed from drug injection to complete sensory block achieved in all dermatomes. Motor block onset time is the time elapsed from injection of study drug to complete motor block. After complete sensory and motor blocks is achieved, the distal tourniquet will be inflated to 250 mmHg, and the proximal tourniquet will be released and the surgery will be s started.
MAP, HR and SPO2 level will be recorded before application of tourniquet and after the application of tourniquet every five minute and were measured after release of the tourniquet, and postoperatively at 30 min, 1 hr, 2 hr, 3 hr, 4 hr, 6 hr and 24 hours. Pain due to the tourniquet will be ssessed with visual analogue scale (VAS) scores (0 = no pain and 10 = worst pain imaginable).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 20-60 years with American society of anesthesiologists physical status I or II undergoing minor hand or forearm surgeries (duration of surgery 60 min or less, such as carpal tunnel release, ganglion excision, trigger finger, tendon or nerve repair, and fracture finger or metacarpal bone) .
排除标准
- •Patients with Raynaud's disease,
- •history of drug allergy, sickle cell anemia, Liver diseases and kidney diseases
- •Patients who had a history of allergy to the drugs used, recent or chronic use of analgesics,
- •uncontrolled hypertension, diabetic neuropathy, peripheral ischemia, , or any psychological disturbances
研究组 & 干预措施
Lidocaine only
Lidocaine intravenous in a dose of 3 mg/kg lidocaine 0.5% diluted in 40 ml isotonic saline for intravenous regional anesthesia.
干预措施: Lidocaine Hydrochloride 2% (Drug)
0.5 ug/kg dexmedetomidine
Lidocaine intravenous in a dose of 3 mg/kg lidocaine 0.5% diluted in 40 ml isotonic saline (maximum dose200 mg)+ Dexmedetomidine intravenous in a dose of 0.5 ug/kg, with the total volume diluted to 40 ml with normal saline 0.9%. The solution will be injected at a rate of 20 ml/min for intravenous regional anesthesia.
干预措施: Dexmedetomidine 0.5 ug/kg (Drug)
0.25 ug/kg dexmedetomidine
1 Lidocaine intravenous in a dose of 3 mg/kg lidocaine 0.5% diluted in 40 ml isotonic saline (maximum dose200 mg)+ Dexmedetomidine intravenous in a dose of 0.25 ug/kg, with the total volume diluted to 40 ml with normal saline 0.9%. The solution will be injected at a rate of 20 ml/min. for intravenous regional anesthesia.
干预措施: Dexmedetomidine Injection 0.25 ug/kg (Drug)
结局指标
主要结局
The time to first analgesic request.
时间窗: 24 hours
if patients starts to complain (VAS \> 3); rescue analgesia will be given in the form of paracetamol (Perfalgan®) 1gm IV drip and/or diclofenac sodium (Voltaren®) 75 mg IM, and/or nalbuphine 5 mg IV (with maximum daily dose of 2 mg/Kg/day) till VAS ≤ 3.And total amount of nalbuphine administered in first 24 hours to each group will be recorded.
次要结局
- Pain due to the tourniquet assessed with visual analogue scale (VAS) scores before and after the application of tourniquet and during the operation(24 hours)
- Levels of sedation assessed with the Ramsey sedation scale before and after the application of tourniquet and during the operation(24 hours)
- The onset, duration times of both sensory and motor blocks, Sensory block onset time, Motor block onset time(24 hours)
研究者
Ghada Mohammed AboelFadl
Principal investigator
Assiut University