Comparison of Peripheral Muscle Strength and Endurance in Chronic Heart Failure Patients and Age, Gender, Body Mass Index Matched Healthy Controls – A Comparative study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- 1) Quadriceps Strength (Handheld Dynamometer)
研究概览
简要总结
Heart failure is prevalent globally, and is associated with increased risk of mortality with increased risk of hospitalization and high health care costs. The aim of this study was to compare the peripheral muscle strength ( Right and left Quadriceps strength) and endurance (1MSTS) in chronic heart failure patients (Group A) and age, gender, body mass index matched healthy controls (Group B) . 30 Chronic heart failure patients (Group A) and 30 age, gender, and BMI matched healthy controls (Group B ) completed the study. Right and Left Quadriceps strength was measured using Hand-held dynamometer. Quadriceps endurance was measured using 1MSTS. Statistically significant reductions were found in peripheral muscle (Right and left quadriceps) strength and endurance (1MSTS repetitions). Thus, the study concluded that the peripheral muscle strength and endurance were reduced in Chronic heart failure patients as compared to age, gender and BMI matched healthy controls.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •For Study Group 1) Chronic heart failure patients for more than 3 months and NYHA class 1 and 2 on OPD basis.
- •Age between 18-65 years males and females.
- •LVEF less than 40% on 2D echo.
- •For Control Group 1) Age, gender and BMI matched healthy individuals.
排除标准
- •For Study Group 1) History of hospital stay in past 3 months.
- •Uncontrolled hypertension with systolic BP more than 140 mm Hg and diastolic BP more than 90 mm Hg and resting heart rate more than 100 beats per minute.
- •Class 3 and Class 4 Angina on NYHA scale.
- •Recent STEMI or Acute coronary syndrome NSTEMI.
- •Patient with any Obstructive Coronary Artery Disease which has not been revascularized.
- •Patients with possible statins Intolerance.
- •Patients with conduction blocks (Grade 1,2,3).
- •Patients with Complex Arrythmias.
- •Patients unable to understand and follow the verbal commands.
- •Patient with any pre-existing musculoskeletal, neurological problems.
- •Patients with any underlying lung pathology or abnormality.
- •For Control Group 1)Systolic blood pressure more than 140 mmHg and less than 100 mmHg. 2)Resting DBP more than 90 mmHg. 3)Resting HR more than 100 bpm .
- •Subjects with any co-morbidities like hypertension, diabetes, any underlying lung pathology.
- •Subjects with any pre-existing musculoskeletal or neurological problems.
- •Subjects with Hypothyroidism.
- •subjects with long term use of statins.
- •Subjects who are unable to understand and follow verbal commands.
结局指标
主要结局
1) Quadriceps Strength (Handheld Dynamometer)
时间窗: 6 months
2) Lower Limb Endurance (1 minute sit to stand repetitions)
时间窗: 6 months
次要结局
未报告次要终点
研究者
Dr Rachna Arora
Topiwala National Medical College and B.Y.L Charitable Hospital