The effect of Deep Brain Stimulation on automatic freeze-fight-flight responses - Fear responses in the deep brain

Radboud Universiteit Nijmegen0 个研究点目标入组 5 人开始时间: 待定最近更新: 2024年4月9日

适应症

试验速览

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•In order to be eligible to participate in this study, a subject must meet all
•of the following criteria:
•- Participant is willing to give informed consent for participation in the
•- Male or Female, aged 18-85 years.
•- Participant is clinically fit.
•- In the investigator*s opinion, is able to comply with all study requirements
•(travel to the Donders Institute, repeatedly concentrate on a computer task for
•±20 min., and perform the task via button presses).
•- Additional inclusion criteria for participants with refractory neuropathic
•o Diagnosed with chronic pain
•o Fitted with Deep Brain Stimulation implants in the periaqueductal grey area
•or the periventricular grey. By definition, in order to be eligible for the
•implants for pain, patients will have failed pharmacotherapy (at least 3
•classes of drugs) and have been through a pain management programme for at
•least three years, including physiotherapy and psychology treatments.

•A potential subject who meets any of the following criteria will be excluded
•from participation in this study:
•The participant may not enter the study if ANY of the following apply:
•- Cardiac problems
•- Anxiety disorders
•- Other comorbidities that would preclude entry into the study, for example if
•a patient had severe physical or mental impairment that would make it difficult
•to sit and focus on the tasks.
•- They feel their deep brain stimulator is not adequately controlling their
•symptoms, or that turning it off for approximately 30 minutes will be
•problematic.

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