Application Study of Individualized Mechanical Power Titration Strategy Based on PiCCO (Pulse Index Continuous Cardiac Output) Monitoring Parameters in ARDS Patients
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 130
- 试验地点
- 1
- 主要终点
- mechanical power
研究概览
简要总结
Based on PiCCO combined with MP, the optimal mechanical power setting of the ventilator for ARDS patients in normal supine/prone position is determined to reduce the damage to lung function during mechanical ventilation. By detecting peripheral serum NLRP3 and related inflammatory markers in ARDS patients, the relationship between NLRP3 and lung injury caused by mechanical ventilation was studied.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Admission to ICU
- •Accept mechanical ventilation, with an expected duration of more than 3 days
- •Diagnose 'ARDS' and meet the criteria for mild, moderate, and severe diagnosis
- •Age over 18 years old
- •Voluntarily participate in the study and sign an informed consent form (if the patient has consciousness disorders, it can be signed by a legal representative)
排除标准
- •There are contraindications for PiCCO monitoring
- •Pregnant or lactating women
- •Recently (within one month) participated in other interventional clinical studies
- •Expected death within 48 hours
研究组 & 干预措施
non-Prone ventilation group
non-Prone ventilation
Prone ventilation group
non-Prone ventilation group
干预措施: Prone position ventilation (Other)
结局指标
主要结局
mechanical power
时间窗: Data were obtained within the first hour post-intubation, at 8:00 AM (±1 h) daily for the subsequent three consecutive days, and during position changes (prone to supine or supine to prone) within these three days.
deep sedation, elimination of spontaneous breathing, measurement via ventilator.Mechanical power (MP) was calculated from the median ventilator parameters via the following equation: mechanical power (J/min) = 0.098× RR × Vt × (PIP - 0.5(Pplateau-PEEP)), where PIP =peak inspiratory pressure. The MP was normalized to the predicted body weight (norMP) = MP/PBW,where PBW was the predicted body weight measured in kilograms.
次要结局
未报告次要终点
研究者
Xu Hao
Head of Department
Xiamen Hospital of Traditional Chinese Medicine