PHARMACEUTICAL ANALYTICAL AND CLINICAL STUDY OF HERBAL NASAL SPRAY FOR ALLERGIC RHINITIS – PILOT STUDY

Allergic Rhinitisis an atopic disease. Allergy is a type-1 hypersensitivity reaction thatproduces IgE antibodies to allergens i.e, pollen, dust, cold, and heat. In Ayurveda, varioussymptoms of Vataja pratishayalike Tanu Nasa Srava,Shirashoola, and Kshavathuare more relevant to symptoms of Allergicrhinitis. Multiple formulations are administered by differentroutes to treat allergic rhinitis. Nasal route act on systemic as well as localdrug delivery route. Different dosage form through nasal routes includes nasalspray, nasal drops, nasal powders, nasal gels, and nasal inserts. Long-termuse of modern nasal sprays can damage the tissue, causing infection and pain.Sometimes it swells even more than before. If the person continues to use it,this swelling can get more severe and lead to permanent swelling of the tissue.Hence Herbal nasal spray may help to overcome these side effects.    Ayurvedamedicine makes up an important component of the trend toward alternativemedicine. Bala is an Ayurvedic medicine that is used to treatInfluenza, Headache, Nasal Congestion, Cough, and Wheezing. Secondly, Haridra has been used for ages in differentinflammatory conditions of the respiratory tract due to active ingredients likecurcumin. Previous research studies proved that Adaraka (Ginger) hasalkaloids Gingerol, gingerdione, and zingiberene which are anti-oxidant,antimicrobial, anti-inflammatory, anti-asthmatic, and Mucolytic in action. The merits of the Nasal delivery route are that it ensures rapid absorption byboth systemic and local drug delivery routes. Also, very few preparations ofNasal Spray are available in Ayurveda pharma companies that signify theindustrial applicability of the product. Hence, in this present study, anattempt will make to prepare an herbal nasal spray for symptomatic treatment ofallergic rhinitis.