ISRCTN16429332进行中（未招募）未知
A parallel-design randomized controlled trial investigating the treatment of metabolic acidosis in patients with chronic kidney disease with either sodium citrate versus sodium bicarbonate
适应症
试验速览
- 阶段
- 未知
- 状态
- 进行中（未招募）
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Age >18 years
- •2. eGFR 15-45 ml/min/1.73 m² CKD EPI
- •3. Serum bicarbonate 10-22 mmol/l on to two different ocassions
- •4. Ability to travel to study visits
- •5. Ability to follow the study treatment regimen
- •6. A wash-out period of one month if previous alkali therapy (such as sodium bicarbonate, sodium citrate, potassium citrate, baking soda, etc)
排除标准
- •1. Hipokalemia <3 meq/l
- •2. Uncontrolled blood pressure (>150/90 mmhg under treatment with more than 3 different classes of antihypertensive drugs, including diuretics)
- •3. Heart failure with active class III or IV New York Heart Association, known left ventricular ejection fraction =30%, or hospital admission for heart failure within the past 3 months
- •4. Hypervolemia of any cause (nephrotic syndrome, liver, or heart failure) considered unsafe for the patient by the PI for the patient
- •5. Active hepatic disease
- •6. Chronic gastrointestinal disorder (treatment adherence unreliable)
- •7. Active malignancy
- •8. Pregnancy
- •9. Patients taking amilorid or sevelamer
- •10. Patients refusing to sign the informed consent
研究者
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