Effect of Upper Body and Lower Body Combined Training (Strength and Endurance) on the Serum Levels of Myostatin and Hormone-sensitive Lipase in Overweight and Obese Men
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 1
研究概览
简要总结
This randomized controlled trial investigated the effects of upper body-based and lower body-based combined training on serum levels of myostatin (MSTN) and hormone-sensitive lipase (HSL) in overweight and obese men. Myostatin is a myokine involved in the regulation of skeletal muscle growth and adipose tissue metabolism, while HSL is a key enzyme involved in lipolysis and fat mobilization.
Thirty-six overweight and obese men were assigned to either an upper body combined training group, a lower body combined training group, or a non-exercising control group. The intervention consisted of 10 weeks of combined resistance and aerobic training performed three times per week. Serum levels of MSTN and HSL were measured before and after the intervention to determine whether upper body-focused and lower body-focused combined training produce different effects on markers associated with muscle growth and lipid metabolism.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
盲法说明
No masking was used in this study. Participants, investigators, and study personnel were aware of group assignments due to the nature of the exercise interventions.
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Male participants aged 20 to 45 years.
- •Body mass index (BMI) ≥25 kg/m².
- •Overweight or obese status.
- •No participation in regular resistance or aerobic exercise during the previous 6 months.
- •Willingness to participate and provide written informed consent.
排除标准
- •Presence of metabolic diseases, including diabetes mellitus.
- •Presence of cardiovascular or respiratory diseases.
- •Musculoskeletal or joint injuries that could interfere with exercise participation.
- •Use of anti-obesity medications.
- •Use of anabolic steroids, sports supplements, or fat-burning supplements.
- •Regular alcohol consumption or tobacco use.
- •Absence from more than two training sessions during the intervention period.
- •Withdrawal of consent or unwillingness to continue participation.
研究组 & 干预措施
Upper Body Combined Training
Participants completed a 10-week upper body-focused combined training program three times per week. Each session consisted of upper body resistance exercises followed by aerobic exercise performed on a hand ergometer. Resistance training included chest press, rowing machine, biceps curl, triceps extension, shoulder press, and abdominal exercises.
干预措施: Upper Body Combined Training (Behavioral)
Lower Body Combined Training
Participants completed a 10-week lower body-focused combined training program three times per week. Each session consisted of lower body resistance exercises followed by aerobic exercise performed on a leg ergometer. Resistance training included leg press, leg extension, leg flexion, leg abduction, leg adduction, and calf raise exercises.
干预措施: Lower Body Combined Training (Behavioral)
Control
Participants in the control group did not participate in the exercise intervention and were instructed to maintain their usual daily activities throughout the 10-week study period.
研究者
Arya Habibi
Principal Investigator
University of Tehran