EFFECTS OF THE ADMINISTRATION OF ANTITHROMBIN ON THE EMOCOAGULATIVE STATE AND ON THE INFLAMMATORY RESPONSE IN PATIENT WITH LOW PLASMATIC LEVELS OF ANTITHROMBIN AFTER CARDIAC INTERVENTIONS - ND

AZIENDA OSPEDALIERA OSPEDALE POLICLINICO CONSORZIALE0 个研究点开始时间: 2010年9月6日最近更新: 2012年10月2日

适应症

试验速览

暂无简介。

•Patients candidates for cardiac surgery intervention in extracorporeal circulation with levels of antithrombin < 65%
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•1) positive history for allergic reactions to AT III 2) cardiac surgery ``Off-Pump`` 3) AdminIstration of AT during surgery or within 48 h earlier (the administration of AT prior to the CEC occurs in patients with resistance all`eparina - ACT <400 sec after administration of heparin 300U/Kg -. Exclusion of these patients is necessary to ensure that in the control group, or in one of two study groups, there are high values of AT preoperative administration). 4) Treatment with drugs and non-steroidal steroids within 48 h prior 5) Coagulatives disorders 6) Platelets <30,000 7) Pre-existing IRC in dialysis treatment 8) Severe liver failure 9) Enlistment in another trial in the last 30 days 10) Spoke in deep hypothermia 11) Interventions in Emergency 12) Reintervention 13) Length of CEC> 180 minutes 14) Subjects incapable of giving legal consent

发起方

AZIENDA OSPEDALIERA OSPEDALE POLICLINICO CONSORZIALE