NCT02128009已完成不适用
Study on the Molecular Mechanism in Postmenopausal Osteoporosis With Kidney Yin Deficiency Syndrome Based on miRNA Mediated Gene Translation Regulation Function by Targeting CLCF1
Fujian Academy of Traditional Chinese Medicine1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2014年2月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- microRNA expression lever in the Peripheral Blood
研究概览
简要总结
The miRNA plays an important regulation role in gene expression, and also closely related to bone metabolism. Previous research found that postmenopausal osteoporosis with kidney Yin deficiency syndrome (POP) is associated with CLCF1 gene. This project proposed by bioinformatics prediction CLCF1 targeted regulation of miRNAs, and use the 3 'UTR dual luciferase report system for target validation, aimed at the miRNA levels to explore postmenopausal osteoporosis molecular mechanism with kidney Yin deficiency syndrome.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 75 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •The Participants who volunteer to be test subjects, and can accept experimental drugs, and promise to finish the course should sign the informed consent.
- •Female ages 45 to 75 had gone through natural menopause before two years
- •In accordance with the western medicine diagnostic criteria of osteoporosis and belong to kidney Yin deficiency syndrome differentiation of traditional Chinese medicine certificate;
- •In accordance with the western medicine diagnostic criteria;
- •In accordance with TCM diagnostic methods; .If any of the above answers are no, The subjects couldn't in the study.
排除标准
- •Do not accord with standard of the western medicine diagnosis and TCM diagnostic methods
- •Age: <44 and > 76 years old;
- •With hyperparathyroidism, osteomalacia, rheumatoid arthritis, multiple myeloma and other serious complications such as secondary osteoporosis; Late or deformity, disability, loss of labor;
- •With cardiovascular, cerebrovascular, liver, kidney and hematopoietic system and other serious primary diseases;
- •Psychosis or alzheimer's patients;
- •Nearly three months, the use of hormone replacement therapy (HRT) and taking calcitonin, nearly six months has used double phosphonic acid salt for 15 days, etc.;
- •This medicine allergic constitution or composition of known to have allergies;
- •In a critical condition, It's difficult to make exact evaluators to efficacy and safety of the new drugs;
结局指标
主要结局
microRNA expression lever in the Peripheral Blood
时间窗: one year
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
已完成
4 期
MiDeTe - microRNA Levels Under Denosumab and Teriparatide Therapy in Postmenopausal OsteoporosisDiabetes Type 2Postmenopausal OsteoporosisNCT03472846Medical University of Vienna26
Unknown
不适用
Roles of microRNAs in the Development of Osteoporosis in Men - Preliminary StudyOsteoporosisNCT02705040Taipei Medical University WanFang Hospital30
已完成
不适用
Circulating Myokine Levels and Bone MetabolismOsteoporosis, PostmenopausalNCT04206618424 General Military Hospital220
Unknown
不适用
Changes in Biochemical Markers of Bone Turnover (Serum CTX and PlNP) After Initiation of a "Drug Holiday" From BisphosphonatesOsteoporosisNCT02575157National Bone Health Alliance120
进行中（未招募）
不适用
MicroRNAs and Cytokines in Peri-Implantitis TissuePeri-implantitisNCT05765942University of Baghdad45