Clinical and patient-reported outcomes in patients receiving Siddha standard of care and allopathic standard of care for psoriasis: A prospective cohort study

This is a prospective cohort study comparing clinical and patient-reported outcomes in two groups, Siddha standard of care and allopathic standard of care in 192 patients ( 96 patients in each group) with psoriasis. This study has been approved by the Kasturba Medical College and Kasturba Hospital Institutional ethics Committee and patients will be recruited only after taking the informed consent. This will be done in the Department of Dermatology, Venereology and Leprosy, Kasturba Hospital, MAHE, Manipal and Division of Siddha, Center for Integrative Medicine and Research (CIMR), MAHE, Manipal. Patients in both the groups will be observed till 4 months of treatment or till the attainment of PASI 75 and from the fifth month up to 1-year, every month patients will be telephonically followed up. The primary outcome measure will be the number of patients reaching  PASI 75. Secondary outcome measures will be the number of relapses in each patient, the number of patients with different grades of remission, time taken to achieve a different grade of remission, duration of remission, assessment of adverse drug reactions, improvement in the patient-reported outcome scores, cost-effectiveness ratio, change in the cytokine levels at the attainment of PASI 75 compared to the baseline level.