NCT00667134已完成不适用
Stimulatory Autoantibodies to the PDGFR and Phosphorylation of the PDGFR in Patients With Systemic Sclerosis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 1
- 主要终点
- Stimulatory autoantibodies to the PDGF receptor
研究概览
简要总结
This study is to determine if subjects with .systemic sclerosis have stimulatory autoantibodies to the PDGF receptor and to confirm activation (phosphorylation) of the PDGF receptor in skin sites with varying degrees of skin thickening
详细描述
Pilot study to assess whether patients with systemic sclerosis have stimulatory autoantibodies to the PDGF receptor and to confirm activation (phosphorylation) of the PDGF receptor in skin sites with varying degrees of skin thickening
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Fulfill the American College of Rheumatology criteria for systemic sclerosis or:
- •Have no diseases that result in primary fibrosis of an organ system, including the skin and do not have an autoimmune disease
排除标准
- •If the subject has systemic sclerosis resulting from an environmental exposure
- •If the subject has an autoimmune disease excluding scleroderma
- •If the subject has an active infection (including, but not limited to hepatitis B, hepatitis C and HIV)
- •If the subject has been treated with cyclophosphamide in the past 8 weeks.
- •If the subject is prone to bleeding because they are on medications that thin the blood or have a low platelet count.
结局指标
主要结局
Stimulatory autoantibodies to the PDGF receptor
时间窗: 1 year
次要结局
- Phosphorylation of the PDGF receptor in patients with systemic sclerosis(One year)
研究者
Kristine Phillips
clinical assistant professor
University of Michigan
研究点 (1)
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