TCTR20180913002招募中2 期
Comparison of inhaled nebulized nitrite and oral sildenafil VS oral sildenafil alonein the treatment of beta-thalassemia patients with pulmonary hypertension
Department of Pharmacology at Faculty of Science, Mahidol University0 个研究点目标入组 50 人开始时间: 2018年9月13日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 100 Years（—）
- 性别
- All
入选标准
- •Age ≥ 18 years old
- •Beta-thalassemia patients diagnosed with pulmonary hypertension type 5 (WHO criteria)
- •Right heart catheterization ; MPAP ≥ 25 mmHg and PCWP < 15 mmHg
- •TR Vmax ≥ 2.8 m/s or RVSP ≥ 35 mmHg will undergo to right heart catherization
排除标准
- •-Currently use organic nitrate
- •-Currently treated with other PAH -specific drugs (except sildenafil)
- •-Hb < 7 mg/dL
- •-Plasma methemoglobin level > 4%
- •-Symptomatic left sided heart failure
- •-History ischemic heart disease
- •-Uncontrolled DM
- •-Uncontrolled thyroid disorder
- •-Cirrhosis
- •-Pregnancy
- •-No inform consent
研究者
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