Characterization of a Novel High-Shear Thrombosis Assay in Normal and Aspirin-treated Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Thrombotic occlusion time
研究概览
简要总结
The purpose of this study is to characterize a new test to assess the rate and time it takes to form a blood clot in people who either do or do not take aspirin.
详细描述
It is estimated that approximately 25% of people are resistant to aspirin, or do not respond to its effect. These individuals have a four fold higher risk of a heart attack or stroke compared to those who respond to aspirin. Current tests for determining those who are aspirin resistant are not reliable. This study is assessing the effectiveness of a new assay in determining the rate and time it takes for people who are or are not on aspirin in forming a blood clot.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •a known bleeding or thrombotic disorder
- •Exclusion Criteria for "new to aspirin" group:
- •a known bleeding or thrombotic disorder
- •have taken aspirin, other NSAIDs, clopidogrel, or an anticoagulant in the previous 10 days
结局指标
主要结局
Thrombotic occlusion time
时间窗: 30 minutes
A microfluidic assay will be used to assess thrombus formation induced by exposed collagen within a stenosis that induces high shear rates. The amount of time taken to completely occlude an aperture is called the thrombotic occlusion time.
次要结局
未报告次要终点
研究者
Sharon Horesh Bergquist
Assistant Professor
Emory University