Impact of Varying Doses of Amino Acids on Exercise, Muscular and Mental Performance
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Isometric strength test
研究概览
简要总结
A number of studies have shown that ingestion of crystalline amino acids, in particular branched chain amino acids (BCAA) can affect endurance performance, markers of muscle damage, and possibly mental focus. It seems that the longer and lower intensity events are affected more by consumption of BCAA. This study will test the hypothesis that BCAA availability limits central fatigue (the feeling of tiredness). While various aspects of performance have been tested no study to date has tested multiple exercise, muscular, and mental performance aspects in a single study. Thus, the overall purpose of this study is to determine whether an amino acid supplement changes the mental and physical response to prolonged exercise versus a placebo (carbohydrate drink).
This nutritional supplement could be useful on two levels. Improved mental focus and endurance performance and decreased central fatigue and muscle soreness could be valuable for enhancing athlete performance. Similarly, decreased central fatigue and muscle soreness may increase the willingness of the general public to exercise which could translate into decreased health risks and increased health benefits.
详细描述
Specific Purpose and Hypotheses
In the current proposal we outline a study that will examine a comprehensive battery of tests to assess the efficacy of Amino Vital's Amino Acid (AA) formulation to improve physical and mental performance after exercise.
We hypothesize:
- Ingestion of the Amino Acid (AA) formula will improve cognitive, motor, and physical performance on the post-exercise tasks in a hierarchical manner: 2AA > AA > placebo
- Blood concentrations of amino acids will be higher in the AA trials in a hierarchical manner: 2AA >AA > placebo
- Markers of muscle damage will be lower than placebo in a hierarchical manner: placebo > AA > 2AA
Recruitment Methods and Process Recruitment methods will be passive. Participants will be made aware of the study through the use of Hamilton Health Science/Faculty of Health Sciences Research Ethics Board (HHS/FHS REB) approved posted flyers at McMaster University and will voluntarily initiate contact with the study team. A recruitment poster will also be submitted for posting on the McMaster Daily News webpage.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Aged 18 to 30 years old
- •Non-obese (body mass index ≤ 30 kg/m2)
- •Non-smoker
- •Healthy (see
排除标准
- •Exclusion Criteria:
- •Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders - all ascertained through medical history screening questionnaire.
- •Arthritic conditions
- •Individuals who cannot refrain from consuming any alcoholic beverages during the study
- •Individuals who chronically consume any analgesic or anti-inflammatory drug(s), prescription or non-prescription
- •A history of neuromuscular problems
- •Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription-strength acne medications)
研究组 & 干预措施
Carbohydrate Placebo
干预措施: AminoVital Amino Acid formulation (Dietary Supplement)
Single Dose
The Amino Vital Focus Zone is a dietary supplement of amino acid mixture, which also contains some minerals, vitamin C, flavour, and sweetener, and its appearance is clear to slightly opaque powder. The Amino Vital Focus Zone contains the five kind of amino acid (L-Leucine, L-Isoleucine, L-Valine, L-Arginine, and L-Glutamine), Citric acid, Vitamin C, some mineral, and sweetener.
Powdered treatments will be dissolved in water and administered orally. This treatment will contain 0.96 g of amino acids.
干预措施: Amino Vital Amino Acid formulation (Dietary Supplement)
Double Dose
The Amino Vital Focus Zone is a dietary supplement of amino acid mixture, which also contains some minerals, vitamin C, flavour, and sweetener, and its appearance is clear to slightly opaque powder. The Amino Vital Focus Zone contains the five kind of amino acid (L-Leucine, L-Isoleucine, L-Valine, L-Arginine, and L-Glutamine), Citric acid, Vitamin C, some mineral, and sweetener.
Powdered treatments will be dissolved in water and administered orally. This treatment will contain 1.92 g of amino acids.
干预措施: Amino Vital Amino Acid formulation (Dietary Supplement)
结局指标
主要结局
Isometric strength test
时间窗: Two Months
Measured on a Biodex leg extension machine. Subjects performed a 5 second voluntary maximal isometric contraction and peak torque was measured.
Stroop Test
时间窗: Two months
The Stroop test is a neuropsychological test to discern the subject's reaction time and cognitive processing speed. Subjects completed four subtasks in this test consisting of vocalizing the colour of boxes; random words; congruent word and colour; and incongruent word and colour.
Wing-Kristofferson Two-Model Test
时间窗: Two months
Subjects will tap their index finger to the beat of a metronome for 10 seconds (synchronization). The metronome will be stopped and the subject will continue tapping for 20 seconds (continuation).
Muscle Damage Markers
时间窗: Two months
Measurement of serum concentrations of creatine kinase (CK), lactate dehydrogenase (LDH), myoglobin, C-reactive protein (CRP).
次要结局
- Blood Glucose and Lactate(Two months)
- Plasma amino acid concentrations(Two months)
- Rating of Perceived Exertion(Two months)