ISRCTN71141922已完成未知
Antibiotic targeting of wolbachia endosymbiotic bacteria as a new approach to the treatment of filarial (Onchocerca Volvulus) infection and disease
European Commission (Belgium)0 个研究点目标入组 67 人开始时间: 2006年7月6日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 67
研究概览
简要总结
2008 results in: https://www.ncbi.nlm.nih.gov/pubmed/17999080 (added 09/05/2019)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •All male or female subjects, aged 18-50 years, who have given informed consent (written or thumb print) were evaluated. Minimum body weight criteria is >40 kg. Participants were then included only if they met the following criteria:
- •1. Normal renal and hepatic laboratory profiles for aspartate aminotransferase (AST) (0-40 IU/l), alanine aminotransferase (ALT) (0-45 IU/l)
- •2. Creatinine 53-126 µmol/l as measured by dipstick chemistry
- •3. More than two palpable onchocercomas
- •4. Microfilarial (Mf) counts >10 Mf/mg (skin biopsies)
排除标准
- •1. Pregnancy (pregnancy test)
- •2. Lactation
- •3. Intolerance to ivermectin or doxycycline
- •4. Chronic diseases
- •5. Alcohol or drug abuse
- •6. Anti-filarial therapy within the last two years
研究者
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