跳至主要内容
临床试验/NCT04107363
NCT04107363已完成不适用

The Effect of Oropharyngeal Aspiration Before Position Change on Reducing the Incidence of Ventilator-Related Pneumonia

Ayşe AKBIYIK0 个研究点目标入组 40 人开始时间: 2015年7月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
40
主要终点
Incidence of Ventilator-Related Pneumonia

研究概览

简要总结

Ventilator-associated pneumonia (VAP) is one of the healthcare-related infections that is common in critically ill patients, prolongs hospital stay, significantly increases mortality and additional health care costs.

Microaspiration of oropharyngeal secretions the primary pathway in the formation of VAP has led researchers to focus on the detection of applications to prevent microbial colonization. Continuous or intermittent oropharyngeal aspiration, open system aspiration versus closed system aspiration, extensive oral care, oropharyngeal aspiration prior to patient positioning are some of these applications.

When the patient is turned to position, the outbreak accumulated in the oral cavity is more likely to move to the lower respiratory tract. In this study, it is assumed that aspiration of oropharyngeal secretions prior to each position change will reduce the accumulation of oral secretion in the endotracheal tube cuff and reduce aspiration of contaminated secretion and reduce the risk of developing VIP. This randomized controlled experimental study was planned to confirm the validity of this assumption.

This study was a randomized controlled experimental study designed to investigate the effect of oropharyngeal aspiration on decreasing the incidence of ventilator-associated pneumonia in patients receiving mechanical ventilation. The research was conducted between July 2015 and April 2019 in anesthesiology and reanimation intensive care unit. The study was carried out with 20 patients who underwent oropharyngeal aspiration as needed and 20 patients with oropharyngeal aspiration prior to each change of position.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Prevention
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Over 18 years of age,
  • Supported mechanical ventilation by endotracheal tube,
  • ≥ 24 hours remaining connected to mechanical ventilator,
  • Position can be changed every 2 hours during the day and 4 hours at night,
  • Patients whose relatives were approved to participate in the study.

排除标准

  • Pneumonia develops prior to mechanical ventilation support or within the first 48 hours following mechanical ventilation support,
  • Positive sputum culture was taken before mechanical ventilation support or within the first 48 hours following mechanical ventilation support,
  • Patients with diabetes mellitus,
  • Patients with contraindications for routine change of position

结局指标

主要结局

Incidence of Ventilator-Related Pneumonia

时间窗: Through study completion, about four years]

Clinical Pulmonary Infection Score (CPIS) was used in the diagnosis of VAP and, VAP was diagnosed in patients whose CPIS was above 6 in the evaluation. Broncho alveolar lavage specimens were cultured for VAP agent/s. Antibiotic susceptibility of microorganisms grown in positive cultures were investigated.

次要结局

未报告次要终点

研究者

发起方
Ayşe AKBIYIK
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Ayşe AKBIYIK

Doctor of Philosophy (PhD) Research Assistant

Izmir Katip Celebi University

相似试验