Computed Tomography Versus Exercise Testing in Suspected Coronary Artery Disease
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 350
- 试验地点
- 4
- 主要终点
- Chest pain
研究概览
简要总结
Direct non-invasive coronary imaging by computed tomography (CT) has the potential to improve the workup of patients with stable chest pain complaints. The objective of the study is to compare in a randomized fashion the effectiveness and efficiency of a CT angiographic driven workup of suspected coronary artery disease in comparison to the standard workup using stress testing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men and women aged >18 years.
- •Stable symptoms of chest pain or dyspnea potentially caused by obstructive CAD.
排除标准
- •A history of surgical or percutaneous coronary revascularization
- •Non-revascularized angiographic obstructive coronary artery disease (>50% diameter reduction).
- •Normal invasive coronary angiography or stress imaging less than 1 years ago.
- •Inability or unwillingness to provide informed consent.
研究组 & 干预措施
Cardiac CT
Cardiac CT (CT calcium and/or CT angiography), followed by stress testing, invasive angiography or neither depending on the CT scan result
干预措施: Cardiac CT (Other)
Standard care
Standard diagnostic management, including stress testing and/or invasive angiography
干预措施: Standard care (Other)
结局指标
主要结局
Chest pain
时间窗: 1 year
Reduction of chest pain symptoms by standardized questionnaire, at one year follow-up
Class IA Revascularizations
时间窗: 1 year
Number of revascularizations with an ESC class 1A indication
次要结局
- Cost-effectiveness(1 year)
- Major adverse cardiovascular events(1 year)
- Overall medical expenses(1 year)
- Radiation dose(1 year)
- Quality of life(1 year)
研究者
Koen Nieman
Dr K Nieman
Erasmus Medical Center