Effects of Prebiotics on GLP-1 in Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 37
- 试验地点
- 2
- 主要终点
- Changes in plasma GLP-1 in response to standardized test meal before and after six weeks of ingestion of prebiotic fibers or placebo
研究概览
简要总结
The aim of the study is to compare the effects of prebiotics versus placebo on blood concentrations of glucagon-like peptide-1 in subjects with diabetes type 2.
详细描述
We looked at 6 weeks supplementation with a prebiotic fibre mix of inulin and FOS. Cross over design compared to maltodextrin as placebo. Additional outcome measures: blood glucose, insulin, GLP-2, ghrelin, PYY and leptin after a standardized mixed meal test. Also measured changes in microbiota composition and SCFA in feces before and after intervention/placebo periods, and subjective measures of appetite.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diabetes type 2
- •BMI 18,5 - 40
- •Not medicated with insulin, GLP-1 analogues or DPP4 inhibitors
- •Moderate intake of alcohol
- •Not excessive exercise
- •Less than 3 kg weight change the last two months
- •Intake of less than 30 g dietary fiber per day
排除标准
- •Coeliac disease
- •Have used antibiotics within the last two months
- •Have used supplements with prebiotics or probiotics the last two months
- •Pregnancy
结局指标
主要结局
Changes in plasma GLP-1 in response to standardized test meal before and after six weeks of ingestion of prebiotic fibers or placebo
时间窗: six weeks
The changes in GLP-1 response to either prebiotic fibers or placebo will be compared in a cross-over manner where the participants are their own controls. In between the intervention periods there will be a wash-out period of 4 weeks.
次要结局
未报告次要终点
研究者
Anne-Marie Aas
Associate professor
Oslo University Hospital