Visual Outcome Evaluation and Genetic Analysis: Shanghai Pediatric Cataract Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 10,000
- 试验地点
- 1
- 主要终点
- Differences in the visual outcomes of pediatric cataract patients.
研究概览
简要总结
The purpose of this study is to evaluate the long-term visual outcome of the cataract surgery using a large-scale and comprehensive database of pediatric cataract participants, including congenital and traumatic cataract. The investigators will further investigate into the various genetic and environmental factors that may contribute to the pathogenesis of pediatric cataract.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Months 至 20 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of pediatric cataract
- •Must be able to cooperate with the ophthalmic examination
排除标准
- •Clinical diagnosis of mental illness
- •Mentally disabled
结局指标
主要结局
Differences in the visual outcomes of pediatric cataract patients.
时间窗: Follow-up until ten years after surgery.
Visual outcomes are evaluated including visual acuity with or without correction, refractive changes, intraocular pressure, fundus function, fixation type, vision development, growth of axial length, contrast sensitivity and other visual outcome measurements.
Genetic diversity based on biospecimen samples of pediatric cataract patients.
时间窗: Analyzed within six months after surgery.
Sequencing of genes (including exons, promoters, 5' UTR and 3' UTR sequences) on a large scale to intensively investigate into the sites and functions of single nucleotide polymorphism (SNP) correlated with clinical features of congenital cataract patients, compared to traumatic cataract patients.Samples of blood, aqueous humor, anterior capsular membranes and lens tissues were applied for the genetic analysis.
次要结局
- Differences in the clinical phenotypes of pediatric cataract patients.(Evaluated before receiving the cataract surgery.)