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临床试验/NCT07487233
NCT07487233尚未招募不适用

Diagnosis of Prolonged Grief Disorder (PGD) Among Older Adults: Mapping Physicians' Knowledge and Practice, and Evaluating the Effectiveness of a Brief Targeted Training Program

Ruppin Acdemic Center0 个研究点目标入组 198 人开始时间: 2026年3月31日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
198
主要终点
Change in PGD Diagnostic Knowledge and Application

研究概览

简要总结

Background: Prolonged Grief Disorder (PGD) is a psychiatric diagnosis with significant implications for individuals and society. Familiarity with its diagnostic criteria and recommended interventions is essential for early detection and effective treatment. As aging naturally involves multiple losses, older adults are at distinct risk of developing PGD, a condition associated with psychological and physical comorbidities and increased mortality. In the Israeli context, this issue holds particular significance following the events of October 7, 2023, and the ensuing war, which have had - and continue to have - a profound impact on the population's mental health. Given PGD's recent inclusion in diagnostic manuals, many physicians may lack sufficient knowledge, leading to under-recognition or misdiagnosis. This gap is particularly evident among older adults, for whom the assessment and management of psychological distress are often underassessed and undertreated, highlighting the urgent need for targeted training and broader integration of existing knowledge into clinical practice. Accordingly, the present study has two main objectives: (1) to assess physicians' knowledge and use of PGD diagnostic criteria with older patients, and (2) to evaluate the effectiveness of a brief informational intervention on their understanding and diagnostic application.

Methods: Using a mixed experimental design, the study will include senior physicians and residents specializing in geriatrics, psychiatry, and family medicine. Data will be collected via an online structured questionnaire containing professional background items and clinical vignettes designed to assess participants' knowledge and application of PGD diagnostic criteria. Afterwards, participants will be individually randomized (1:1) via a computer-generated sequence in a partially participant-blinded, assessor-blinded controlled trial to either an experimental group viewing an informational PGD video or a control group viewing a structurally equivalent video (matched in length, graphics, and word count) addressing bereavement in older adults without directly referencing PGD. All participants will then complete the vignettes again to evaluate the effects of the intervention.

Discussion: This first systematic Israeli study on PGD implementation will provide an empirical basis for policy development, professional training, and prevention programs. Its findings may enhance diagnostic accuracy, improve care efficiency, reduce systemic costs, and support ongoing evaluation and refinement of clinical practices.

详细描述

Background Prolonged Grief Disorder (PGD) is a mental health condition recently included in the ICD-11 [1] and DSM-5-TR [2]. It is characterized by unique core symptoms, including intense yearning for the deceased, persistent preoccupation with the deceased, or both. These symptoms are commonly accompanied by emotional pain, disruption of personal identity, loss of meaning and purpose in life, and impaired daily functioning [3]. PGD is distinct from other psychiatric diagnoses such as Major Depressive Disorder, Generalized Anxiety Disorder, and Post-Traumatic Stress Disorder, and is associated with a range of negative outcomes, including physical health problems [4], increased risk of suicidal ideation or attempts, reduced life satisfaction, functional impairment, and greater utilization of health services. Epidemiological studies indicate that among bereaved populations, the prevalence of PGD is relatively low in representative samples (approximately 3-4%), while higher rates, up to 16%, are reported in non-probability or convenience samples [5].

Aging is naturally accompanied by experiences of loss and bereavement, and as individuals age, they encounter an increasing number of losses, including traumatic ones and various life-course separations. Consequently, older adults are considered at elevated risk for disruptions in the normative grief process in general, and for the development of PGD in particular [6, 7]. Supporting evidence includes, for example, a meta-analysis of over 60,000 participants, which identified spousal loss and pre-death grief (experienced while caring for a terminally ill relative) as two major risk factors for PGD [8]. Both phenomena, whose prevalence increases with age, illustrate older adults' heightened vulnerability to the loss of significant others and its adverse consequences. Additionally, multiple studies have linked the loss of a close person, especially a spouse among older adults, to serious health outcomes, including immune dysfunction, increased cardiovascular risk, chronic pain, and even elevated mortality rates [e.g., 9-11].

These findings indicate that PGD not only impacts individual quality of life but also imposes a significant economic burden on healthcare systems. Additional costs include medical treatments, medications, hospitalizations, and mental health services, alongside impaired daily functioning and productivity. Early identification and tailored intervention can therefore improve patient outcomes while reducing systemic costs [e.g., 12-14] Consistent with the gap between academic research and its systematic application in clinical practice [15], healthcare providers' knowledge of complications in the normative grief process is often limited [16]. Furthermore, given that PGD is a relatively new diagnosis not yet widely recognized among clinicians, raising awareness among physicians and mental health professionals is crucial for enabling early identification and appropriate intervention [6]. This issue is especially relevant for older adults, given the evidence of underdiagnosis and undertreatment of psychological distress in this population [e.g., 17, 18].

For example, although suicide rates among older adults in Israel and globally are higher than in any other age group, epidemiological studies show that the prevalence of clinically significant depression and anxiety is comparatively lower in older adults than in younger populations. Moreover, older adults with depression often report fewer typical cognitive-emotional symptoms (e.g., dysphoria, guilt, or feelings of worthlessness) and instead emphasize physical symptoms such as fatigue, somatic complaints, and difficulties with memory and concentration [19].

In fact, research indicates that many older adults who engaged in suicidal behavior had visited a physician shortly beforehand, yet their psychological distress remained undetected. This phenomenon stems, in part, from a lack of knowledge and appropriate skills among healthcare professionals regarding assessment and treatment in older populations. Additionally, research indicates the presence of ageist attitudes among clinicians, manifesting, for example, in reduced confidence in the effectiveness of interventions for the elderly. At the same time, many older adults avoid seeking mental health care for generational, social, personal, or practical reasons, making the primary care physician often the sole gateway to identifying psychological distress and referring patients for appropriate care [19]. These findings highlight the need for targeted professional training to enhance understanding of the clinical characteristics unique to older adults and to facilitate effective, tailored intervention.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Diagnostic
盲法
Double (Participant, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Licensed physicians (specialists or residents) in geriatrics, psychiatry, or family medicine
  • Provide informed consent to participate

排除标准

  • Individuals not meeting the inclusion criteria

结局指标

主要结局

Change in PGD Diagnostic Knowledge and Application

时间窗: Baseline and immediately post-intervention

Change in the number of correct responses to clinical vignettes from baseline to post-intervention, comparing experimental and control groups.

次要结局

  • Differences in PGD Knowledge by Medical Specialty(Baseline)

研究者

发起方
Ruppin Acdemic Center
申办方类型
Other
责任方
Sponsor

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