Effects of Acute Intermittent Hypoxia on Sensory Function in Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Sensory Function
研究概览
简要总结
Exposure to acute intermittent hypoxia (AIH) can facilitate of motor output but no studies of sensory effects has been reported.
详细描述
Despite the strong results of motor studies, the affects of AIH on sensory function has not been established. We will use a commercially-available hypoxicator that can be programmed to achieve a targeted level of arterial oxygen saturation. We plan to compare 3 previously published protocols that have generated motor facilitation (and a sham condition) to characterize and effects on sensory function in healthy adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
Participants can't see the device and therefore the settings. The assessment of sensory function is done by a separate investigator who did not participate in the set up of the hypoxicator
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 to 40 years of age
排除标准
- •Diagnosis of cardiovascular disease (Hypertension, arrhythmias, coronary artery disease, congenital and valvar heart diseases)
- •Diagnosis of neuromuscular disease
- •Diagnosis of any neurological disease
- •Presence of concurrent medical illness including infection, fractures
- •Diagnosis of obstructive sleep apnea
- •Diagnosis of obstructive/restrictive lung disease
- •Diagnosis of exercise induced asthma
- •FEV1/FVC<80% and/or FVC<80% of predicted value indicating airway obstruction
- •Subjects on prednisolone therapy or selective serotonin reuptake inhibitor (SSRI) therapy will be excluded from the study as these pharmacological agents are known to amplify the effects of IH[22, 23]
- •Diagnosis of epilepsy or history of seizures and attention deficit disorders
- •Pregnancy
- •History of coagulation disorders
- •History of chronic pain
- •Body mass index(BMI)> 35kg/m2
- •Subjects on prescription medicines such as beta blockers and other drugs that are prescribed in any of the exclusionary disorders listed above.
结局指标
主要结局
Sensory Function
时间窗: Every 10 minutes for 60 minutes post intervention, average reported
Thermal thresholds. Average reported.
Temporal Sensory Summation
时间窗: Every 10 minutes for 60 minutes post intervention, average reported
Temporal summation represents increases in ratings of pain intensity measured using a numeric pain rating scale (0-no pain to 100-worst pain imaginable) to repeated heat stimuli of the same intensity; that is, "summation" represents increases in participant ratings of pain despite the maintenance of a standard temperature and is calculated as the difference between pain rating 1 and pain rating 6. Positive difference scores indicate that pain reported increased over the 6 pulses of heat. Here, the average difference across participants and over time is reported.
Sensory Function - Pressure
时间窗: Every 10 minutes for 60 minutes post intervention, average reported
Pressure threshold is the force at which the sensation of pressure first is considered painful by the participant, average reported
次要结局
未报告次要终点