NCT03335514已完成不适用
Changes of GALNT4 and the Relationship With PSGL-1on Monocytes and Hs-CRP in Blood of Patients With Coronary Heart Disease
The First Affiliated Hospital of Dalian Medical University1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2017年9月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- the expression of GALNT4
研究概览
简要总结
The expression of GALNT4 in blood with acute coronary syndrome
详细描述
Emerging evidences have linked GALNTs to cardiovascular disease or susceptibility to CAD.GALNT4, a member of the GalNAc-Ts family,contributes to the initiation of O-linked. Polymorphisms in GALNT4 have been linked with incidence of MI in an Irish population, probably that O-glycosylation of PSGL-1 by GalNAc-T4 may be important for many P-selectin mediated inflammation.However, there is few relevant studies about the expression of GALNT4 in patients with acute coronary syndrome.This study valuates the expression of GALNT4 in patients with acute coronary syndrome.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosed as acute coronary syndrome,including STEMI,NSTE-ACS,or diagnosed as SAP by CAG.
- •with left ventricular ejection fraction（LVEF）>=45%
- •written informed consents are obtained
- •admitted within 24 hours after chest pain attacked(except SAP)
排除标准
- •• complicated with rheumatic heart disease, coronary arteritis, hypertrophic cardiomyopathy or dilated cardiomyopathy
- •complicated with malignant tumor,the immune system diseases, blood system diseases, recently (within 2 weeks) taking glucocorticoid drugs, the use of immunosuppressive agents and cerebral infarction
- •with acute or chronic infection, surgery or trauma in the last month
- •secondary hypertension, severe liver dysfunction,severe renal insufficiency
- •with abnormal thyroid function or allergy to iodine agent
- •refusal to sign the informed consent
结局指标
主要结局
the expression of GALNT4
时间窗: 12 months
Realtime RCR measure the expression of galnt4 in peripheral blood
次要结局
- MACEs during 12-month follow-up(12 months)
研究者
研究点 (1)
Loading locations...
相似试验
尚未招募
不适用
Identification of Serum Level of Glutathione Peroxidase 4SpondyloarthropathyNCT06554392Assiut University85
撤回
不适用
Interleukin-4 (IL-4) as a Marker of AtherosclerosisIschemic Heart DiseaseAtherosclerosisNCT00256035Melbourne Health
Unknown
不适用
Plasmablast Detection From IgG4-Related Disease PatientsIgG4-related DiseaseNCT03466970Meir Medical Center40
Unknown
不适用
The Correlation Between Genetic Polymorphism, Platelet Activity, Clopidogrel Responsiveness, and Serum Adipokine Concentration in Asian Acute Coronary Syndrome PatientsChronic Coronary Artery DiseaseAcute Coronary SyndromeNCT01255267China Medical University Hospital
已完成
不适用
Prognostic Value of Plasma DPP4 Activity in ST-elevation Myocardial Infarction PatientsCoronary AngiographyDipeptidyl Peptidase 4NCT03046576Chinese PLA General Hospital625