Perioperative myocardial injury (MINS) and coronary microvascular dysfunction in cMRI - MINS-cMRT

niversitätsmedizin Göttingen0 个研究点目标入组 180 人开始时间: 2024年5月2日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•Patients undergoing orthopaedic trauma surgery with medium to high surgical risk
•o Operations on the spine, hip joint replacement
•At least 1 risk factor for CMD
•o CMD risk factors: female gender, advanced age, arterial hypertension, obesity p.m., hyperlipidaemia, diabetes mellitus, chronic renal insufficiency, smoking. renal insufficiency, nicotine consumption.

•- Age <18 years
•- Pregnancy and breastfeeding
•- Operations on patients with congenital heart defects
•- Operations on patients with long-term corticosteroid therapy
•- Patients with calcium antagonists and/or nitrates in prior medication
•- Emergency operations
•- Patients with cardiac devices and post heart valve replacement (regardless of MRI compatibility)
•- Patients with Raynaud's syndrome and/or PAD and/or vasculitis
•- Exclusion criteria due to contraindications for adenosine
•o Hypersensitivity to adenosine
•o AV block II. or III. degree (except for patients with a functioning pacemaker)
•o sick sinus syndrome
•o Atrial fibrillation or flutter; patients who have atrial fibrillation or flutter and an additional (accessory) conduction pathway between the atrium and ventricle may exhibit accelerated conduction and thus develop an increased ventricular rate
•o Chronic obstructive pulmonary disease with bronchospasm (e.g. bronchial asthma)
•o prolonged QT interval, regardless of whether this is congenital, induced by a substance or occurs as a result of a metabolic event, as torsade de pointes can be triggered
•o severe hypotension
•o decompensated heart failure
•o concomitant use with dipyridamole (due to up to 4-fold increase in the effect of adenosine)

发起方

niversitätsmedizin Göttingen