A Retrospective Study on the Effect of HBA or HBB Genetic Defects on Early Embryonic Development
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 737
- 试验地点
- 1
- 主要终点
- Gardner grading of blastocysts
研究概览
简要总结
Thalassemia is an anemia or pathological state caused by compounding absently or inadequately of one or more globin chains of hemoglobin due to the defects of the globin gene,and the carrying rate is high in southern China. Although there are many studies of Thalassemia, the relationship between the globin gene defects and the early embryo development has not been reported.
This study intends to carry out a retrospective analysis on the embryonic development of the patients with thalassemia assisted by PGD from January 1, 2011 to now in our hospital, to explore whether the HBA or HBB gene defects have a certain influence on the early embryo development, so as to accumulate certain data for reproductive health research.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •infertility couples with thalassemia(one or both )
- •infertility couples treat by PGD
排除标准
- •abortion of amplification for blastula biopsy
- •PGD without diagnostic results or with unclear diagnostic results
- •embryos with both HBA and HBB genetic defect
结局指标
主要结局
Gardner grading of blastocysts
时间窗: embryo cultured in-vitro for 5-7 days
development status of blastocysts
次要结局
未报告次要终点