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临床试验/NCT04875403
NCT04875403Unknown不适用

Physical Functional Impacts of Rehabilitation in Patients With Human Lymphotropic Virus Type I

Universidade Metodista de Piracicaba2 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2021年4月27日最近更新:
适应症

试验速览

阶段
不适用
入组人数
40
试验地点
2
主要终点
Respiratory muscular strenght

研究概览

简要总结

In our times, it is known that approximately 5% of patients seropositive for HTLV-1 may desengage a frame with several neurological disorders, which is called myelopathy associated with HTLV-1, characterized for gait, decreased dynamic balance and limitation of walking independence the use of walkers, crutches as in wheelchairs. This evolution of the disease is based, above all, on muscle changes, such as inflammation of the muscles, which contributes to the attenuation of muscle capacity . In addition, muscle changes caused by HTLV-1 also affect the respiratory muscles, causing a change in respiratory mechanics, which can impair alveolar ventilation and, therefore, the development of a restorative respiratory disorder, reducing total lung capacity. Therefore, it is perceived the importance of offering planned rehabilitation according to the global assessment of the health status of these patients, considering their influence on activities of daily living.The focus of this study is on the weekly respiratory muscle training, as assessed by mensuration maximal inspiratory pressure, showed significant results in improving lung capacity and in this way promoting the prevention of pulmonary complications. Therefore, the protocol proposed by the present study includes respiratory muscular training plus resistance exercise, assessing the impact on both the strength muscular respiratory to as peripheral muscles, through the palmar pressure test and consequent enhancement of quality life and functionality of these patients. Furthermore, it will be possible to contribute to the knowledge of society and the scientific community about this theme, which is still very small in the world literature.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
40 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Seropositive carriers for HTLV-1 with PET

排除标准

  • lung diseases
  • heart disease
  • arterial hypertension
  • cognitive impairments

结局指标

主要结局

Respiratory muscular strenght

时间窗: from baseline respiratory muscle stenght to 5 weeks

The assessment of respiratory muscle strength will be carried out weekly by measuring the maximum inspiration pressure

Functional capacity

时间窗: from baseline functional capacity to 5 weeks

The assessment of functional capacity will be carried out weekly by six minute walk test

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Rodrigo Santiago Barbosa Rocha, Phd

Researcher

Universidade Metodista de Piracicaba

研究点 (2)

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