STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI): a multi-centre, randomized, controlled trial

niversity of Toronto0 个研究点目标入组 2,927 人开始时间: 2019年2月18日最近更新: 2023年8月21日

适应症

试验速览

2020 Results article in https://doi.org/10.1056/NEJMoa2000741 (added 18/11/2022)

•1. Age =18 years
•2. Admission to an intensive care unit (ICU)
•3. Evidence of kidney dysfunction [serum creatinine =100 µmol/L in women and = 130 µmol/L in men]
•4. Evidence of severe AKI

•1. Lack of commitment to provide RRT as part of limitation of ongoing life support.
•2. Presence of a drug overdose that necessitates initiation of RRT.
•3. Any RRT within the previous 2 months.
•4. Kidney transplant within the past 365 days.
•5. Known pre-hospitalization advanced chronic kidney disease, defined by an estimated glomerular filtration rate <20 mL/min/1.73 m2 in a patient who is not on chronic dialysis.
•6. Presence or clinical suspicion of renal obstruction, rapidly progressive glomerulonephritis, vasculitis, thrombotic microangiopathy (eg, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, malignant hypertension, scleroderma renal crisis) or acute interstitial nephritis.
•7. Likelihood that an absolute indication for RRT will arise in the subsequent 24 hours based on the most recent blood work for the following parameters: serum K >5.5
•8. Likelihood that an absolute indication for RRT will arise in the subsequent 24 hours based on the most recent blood work for the following parameters: serum bicarbonate <15 mmol/

发起方

niversity of Toronto