CTRI/2025/03/081734尚未招募2 期
Comparison of preoperative nebulization with lignocaine versus ketamine in prevention of sore throat in patients undergoing general anaesthesia
Shivani Sharma1 个研究点 分布在 1 个国家目标入组 300 人开始时间: 2025年3月17日最近更新:
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- To assess and compare the intensity of Post-Operative sore throat in patients with Pre-Operative nebulization with lignocaine and ketamine undergoing general anaesthesia with endotracheal intubation.
研究概览
简要总结
Group K- It includes patients nebulized with ketamine 50 mg (1ml)+ Normal saline (1ml)
Group L- It includes patients nebulized with Lignocaine 2% (1ml) + Normal Saline (1ml)
Group C- It includes patients nebulized with Normal saline (2ml)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA grade 1 and 2 2) Age : Between the ages of 18 and 70, enrolled for elective surgery required for 2 hours of endotracheal intubation while under general anaesthesia.
排除标准
- •Patient that decline for participation in trial.
- •Patient allergic to ketamine or lignocaine.
- •Patient cough or bucked during intubation and extubation.
- •BMI more than 35 kg/ meter square.
- •Patient with history of previous sore throat or taking steroids or analgesia in last 48 hours 6) COPD, asthma, neuromuscular disease, difficult intubation.
结局指标
主要结局
To assess and compare the intensity of Post-Operative sore throat in patients with Pre-Operative nebulization with lignocaine and ketamine undergoing general anaesthesia with endotracheal intubation.
时间窗: Hemodynamic variables will continued to be monitored at baseline to 4 hours, 6 hours, 12 hours and then 24 hours.
次要结局
- To evaluate the hemodynamic alterations and side effects, such as sedation, dry mouth, nausea, cough and vomiting during the study.(24 hours)
研究者
Dr Shivani Sharma
Maharishi Markandeshwar Medical College
研究点 (1)
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