The Effect of Low Calorie Sweetener Consumption on Body Weight, Body Composition, Appetite, and Energy Intake
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 187
- 试验地点
- 2
- 主要终点
- Body Weight
研究概览
简要总结
The aim of this study will be to compare the effects of daily consumption of aspartame, rebaudioside a, saccharin, sucralose, and sucrose on body weight and composition in a standardized protocol. The investigators hypothesize that individual low calorie sweeteners (consumed in a beverage) differ from each other in promoting weight loss and decreased fat mass (without energy restriction or dietary guidance) based on their chemical structure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI between 25-40 kg/M2
- •Non or rare users of LCS
- •Willing to consume large volumes of beverages daily
排除标准
- •Weight change > 3kg in the last year
- •Plan to initiate a new diet plan in the next 6 months
- •Exhibit eating restraint
- •Pregnant/lactating
研究组 & 干预措施
Rebaudioside A Sweeteened Beverage
0.250-0.350 g rebaudioside A Sweetened Beverage/day
干预措施: Beverage (Dietary Supplement)
Saccharin Sweetened Beverage
0.300-0.455 g saccharin Sweetened Beverage/day
干预措施: Beverage (Dietary Supplement)
Sucrose Sweetened Beverage
100-140 g sucrose/day
干预措施: Beverage (Dietary Supplement)
Aspartame Sweetened Beverage
0.541-0.757 g aspartame Sweetened Beverage/day
干预措施: Beverage (Dietary Supplement)
Sucralose Sweetened Beverage
0.167-0.233 g sucralose Sweetened Beverage/day
干预措施: Beverage (Dietary Supplement)
结局指标
主要结局
Body Weight
时间窗: 12 weeks
Energy Intake
时间窗: 12 weeks
24 hr Dietary Recall
Appetite
时间窗: 12 weeks
24 hr visual analog scale appetite
Body Composition
时间窗: 12 weeks
Duel emission X-ray absorbtiometry
Energy Expenditure
时间窗: 12 weeks
accelerometer
次要结局
未报告次要终点
研究者
Richard Mattes
Distinguished Professor of Nutrition Sciences
Purdue University