Effects of Diet Type Selection Based on Response to a Carbohydrate Intolerance Questionnaire and Genetic Screening on Success to a Weight Loss and Exercise Program
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 主要终点
- Effects of diet selection on physical activity patterns changes (steps per day)
研究概览
简要总结
The purpose of this study is to determine the effects of diet type selection based on response to a Carbohydrate Intolerance Questionnaire (CIQ) and genetic screening on success to a weight loss and exercise program.
详细描述
The purpose of this study is to determine if stratification of individuals based on responses to a Carbohydrate Intolerance Questionnaire (CIQ), genetic screening, and/or DNA methylation affects weight loss success and/or health outcomes of women following the Curves moderate carbohydrate, high protein, low fat diet (30% carbohydrate, 45% protein, 25% fat) or the Curves carbohydrate restricted, high protein, moderate fat diet (20% carbohydrate, 45% protein, 35% fat).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •The participant is an apparently healthy female
- •The participant is between the ages of 18 and 60
排除标准
- •The participant is pregnant or nursing, or plans to become pregnant during the next 12 months or has been pregnant in the past 12 months
- •The participant has uncontrolled metabolic disorder including known electrolyte abnormalities; heart disease, arrhythmias, diabetes, thyroid disease, or hypogonadism; a history of hypertension, hepatorenal, musculoskeletal, autoimmune, or neurological disease
- •The participant is currently taking thyroid, hyperlipidemic, hypoglycemic, anti-hypertensive, or androgenic medications
- •The participant has taken ergogenic levels of nutritional supplements that may affect muscle mass (e.g., creatine, HMB), anabolic/catabolic hormone levels (androstenedione, DHEA, etc.) or weight loss (e.g., ephedra, thermogenics, etc.) within the past three months
- •The participant is willing to take participate in a regular moderate exercise program
研究组 & 干预措施
Positive CIQ plus High Carbohydrate Diet
Positive Carbohydrate Intolerance Questionnaire (CIQ) plus 30% carbohydrate, 45% protein, 25% fat diet
干预措施: Positive CIQ plus High Carbohydrate Diet (Other)
Positive CIQ plus High Protein Diet
Positive Carbohydrate Intolerance Questionnaire (CIQ) plus 20% carbohydrate, 45% protein, 35% fat diet
干预措施: Positive CIQ plus High Protein Diet (Other)
Negative CIQ plus High Carbohydrate Diet
Negative Carbohydrate Intolerance Questionnaire (CIQ) plus 30% carbohydrate, 45% protein, 25% fat diet
干预措施: Negative CIQ plus High Carbohydrate Diet (Other)
Negative CIQ plus High Protein Diet
Negative Carbohydrate Intolerance Questionnaire (CIQ) plus 20% carbohydrate, 45% protein, 35% fat diet
干预措施: Negative CIQ plus High Protein Diet (Other)
结局指标
主要结局
Effects of diet selection on physical activity patterns changes (steps per day)
时间窗: 24 weeks
Effects of diet selection on body weight changes (pounds)
时间窗: 24 weeks
Effects of diet selection on hip/waist ratio changes (inches)
时间窗: 24 weeks
Effects of diet selection on Resting Energy Expenditure (REE) changes (calories per day)
时间窗: 24 weeks
Effects of diet selection on body composition (DXA) changes (percent fat mass)
时间窗: 24 weeks
Effects of diet selection on Bioelectrical Impedance Analysis (BIA) changes (flow impedance)
时间窗: 24 weeks
Effects of diet selection on a chemistry-15 blood panel changes
时间窗: 24 weeks
Effects of diet selection on Blood Pressure (BP) changes (mmHG)
时间窗: 24 weeks
Effects of diet selection on Heart Rate (HR) changes (beats per minute)
时间窗: 24 weeks
Effects of diet selection on a cell blood count (CBC) blood panel changes
时间窗: 24 weeks
Effects of diet selection on lipid panel changes
时间窗: 24 weeks
次要结局
- Effects of diet selection on muscular endurance through a maximal repetition test(24 weeks)
- Effects of diet selection on muscular strength through a 1 repetition maximum (1 RM) test(24 weeks)
- Effects of diet selection on gene expression changes(24 weeks)
- Effects of diet selection on maximal cardiopulmonary capacity changes (ml/kg/min)(24 weeks)
- Effects of diet selection on DNA methylation changes(24 weeks)