Study if the Presence of Functional FcERI/RII on the Surface of Human Blood Platelet
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Presence of functionnal FcERI/RII receptors on the surface of blood platelets from allergic patients
研究概览
简要总结
Anaphylactic shock is the most severe expression of immediate hypersensitivity reactions. The mechanisms leading to these reactions are still poorly understood and may involve platelets, especially in the most severe forms.
The IgE ( ImmunoglobulineE)-mediated mechanism, involving the FcERI(the high-affinity receptor for the Fc region of immunoglobulin E (IgE) receptor present on the surface of mast cells and basophilic cells, is the most common mechanism. The receptors FcERI and FcERII are also described as being present on the surface of blood platelets, which would imply their activation along with the other cells involved. However, studies showing the presence of the FcERI/RII receptors on blood platelets suffer from many biases.
The main objective of the research is to study whether the FcERI/RII receptors are present and functional on the surface of blood platelets from allergic patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years-old
- •With a protein/drug allergy (hymenoptera, arachide, amoxicillin)
- •Confirmed by skin tests and/or challenge test
- •With specific IgEs
排除标准
- •Patients who refuse to participate to this study
- •Patients unable to consent
结局指标
主要结局
Presence of functionnal FcERI/RII receptors on the surface of blood platelets from allergic patients
时间窗: 1 day
After confirmation of the allergy by a well conducted allergy workup
次要结局
未报告次要终点