A study investigating autonomic dysfunction in chronic cough patients

niversity Hospital of South Manchester NHS Foundation Trust (UK)0 个研究点目标入组 30 人开始时间: 2014年1月23日最近更新: 2019年2月11日

适应症

试验速览

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•1. Chronic cough subjects aged 18 and over or healthy volunteers aged 45 and over
•2. Subject must be able to give informed consent
•3. Normal spirometry
•4. Cough subject only: chronic cough, defined as a cough lasting longer than 8 weeks despite investigation and/or treatment trials for cough variant asthma, post-nasal drip and gastro-oesophageal reflux disease
•5. No significant respiratory diseases (except chronic cough in the patient group)
•6. No known autonomic function disorders, neuropathy or neurological disorders
•7. No history of syncope which is not related to cough
•8. Current alcohol consumption exceeding government guidelines

•1. Asthma, diabetes; cardiovascular disease, hypertension, irritable bowel syndrome (IBS), previous brain injury, history of myocardial infarction or any other disorder deemed unsuitable by the investigator
•2. Current smoker or ex smoker (more than 10 pack years) and those still smoking within 6 months of the start of the study
•3. Regular intense exercise, i.e. competitive sports
•4. Blood pressure over 160/90 or abnormal ECG as determined by a medical doctor on screening
•5. Pregnancy or breast-feeding
•6. Use of angiotensin-converting-enzyme (ACE) inhibitors
•7. Use of centrally acting medications that may affect the cough reflex (pregabalin and opiates may not be taken within 1 week of screening and throughout study)
•8. History of drug or alcohol abuse
•9. Current, treated depression
•10. BMI greater than or equal to 32
•11. Subjects taking anti-hypertensives; beta blockers; calcium channel blockers; anticholinergic medications or antidepressant treatment.

发起方

niversity Hospital of South Manchester NHS Foundation Trust (UK)